Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage.
Anti-inflammation
Carbon monoxide
Ethanol
Gastric mucosal damage
Gastroprotection
NSAID
Prodrug
Journal
Acta pharmaceutica Sinica. B
ISSN: 2211-3835
Titre abrégé: Acta Pharm Sin B
Pays: Netherlands
ID NLM: 101600560
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
31
03
2020
revised:
18
05
2020
accepted:
17
07
2020
entrez:
1
3
2021
pubmed:
2
3
2021
medline:
2
3
2021
Statut:
ppublish
Résumé
Metal-based carbon monoxide (CO)-releasing molecules have been shown to exert anti-inflammatory and anti-oxidative properties maintaining gastric mucosal integrity. We are interested in further development of metal-free CO-based therapeutics for oral administration. Thus, we examine the protective effect of representative CO prodrug, BW-CO-111, in rat models of gastric damage induced by necrotic ethanol or aspirin, a representative non-steroidal anti-inflammatory drug. Treatment effectiveness was assessed by measuring the microscopic/macroscopic gastric damage area and gastric blood flow by laser flowmetry. Gastric mucosal mRNA and/or protein expressions of HMOX1, HMOX2, nuclear factor erythroid 2-related factor 2, COX1, COX2,
Identifiants
pubmed: 33643824
doi: 10.1016/j.apsb.2020.08.005
pii: S2211-3835(20)30688-2
pmc: PMC7893125
doi:
Types de publication
Journal Article
Langues
eng
Pagination
456-475Informations de copyright
© 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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