Primary Cilia in the Skin: Functions in Immunity and Therapeutic Potential.
Langerhans cell
atopic dermatitis
epidermis
immunity
keratinocyte
primary cilia
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
10
2020
accepted:
04
01
2021
entrez:
1
3
2021
pubmed:
2
3
2021
medline:
2
3
2021
Statut:
epublish
Résumé
The skin is the biggest organ and provides a physical and immunological barrier against pathogen infection. The distribution of primary cilia in the skin of mice has been reported, but which cells in human skin have them has not, and we still know very little about how they change in response to immune reactions or disease. This review introduces several studies that describe mechanisms of cilia regulation by immune reaction and the physiological relevance of cilia regulating proliferation and differentiation of stroma cells, including skin-resident Langerhans cells. We discuss the possibility of primary cilia pathology in allergic atopic dermatitis and the potential for therapies targeting primary cilia signaling.
Identifiants
pubmed: 33644059
doi: 10.3389/fcell.2021.621318
pmc: PMC7905053
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
621318Informations de copyright
Copyright © 2021 Toriyama and Ishii.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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