Evaluation of serum endocan levels in relation to epicardial fat tissue thickness in metabolic syndrome patients.
adipose tissue
endothelium
epicardial fat tissue thickness
metabolic syndrome
proteoglycans
Journal
Archives of medical sciences. Atherosclerotic diseases
ISSN: 2451-0629
Titre abrégé: Arch Med Sci Atheroscler Dis
Pays: Poland
ID NLM: 101701205
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
06
2020
accepted:
02
11
2020
entrez:
1
3
2021
pubmed:
2
3
2021
medline:
2
3
2021
Statut:
epublish
Résumé
Metabolic syndrome has been recognized as a predictor of cardiovascular diseases. Epicardial fat tissue (EFT) thickness has recently been shown to be a predictor of cardiovascular diseases in metabolic syndrome patients. Endocan is a novel molecule which is considered to be an early marker of endothelial dysfunction. Our aim was to evaluate endocan serum levels for the first time in metabolic syndrome patients, in relation to EFT thickness. The study included 44 patients with metabolic syndrome who had neither chronic kidney disease nor chronic inflammation and 26 healthy controls. Fasting blood samples were obtained from the groups. The serum levels of endocan were measured with a Sunred ELISA kit. EFT thickness of patients was measured by echocardiography. The serum endocan levels were significantly lower in the metabolic syndrome patients compared to the healthy controls (120.71 ±90.17 pg/ml vs. 414.59 ±277.57, EFT thickness was high in metabolic syndrome patients and can be a useful marker for cardiovascular risk assessment. However, serum endocan levels were found to be low and there was no correlation with EFT thickness. Large sample sized prospective studies are needed to clarify the relation of endocan levels with the other clinical indicators of cardiovascular risk in metabolic syndrome.
Identifiants
pubmed: 33644488
doi: 10.5114/amsad.2020.103031
pii: 43127
pmc: PMC7885812
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e290-e296Informations de copyright
Copyright: © 2020 Termedia & Banach.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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