Sealing holes in cellular membranes.
ESCRT
autophagy
endocytosis
lysosome
membrane repair
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
revised:
29
10
2020
received:
30
09
2020
accepted:
04
11
2020
pubmed:
2
3
2021
medline:
25
2
2023
entrez:
1
3
2021
Statut:
ppublish
Résumé
The compartmentalization of eukaryotic cells, which is essential for their viability and functions, is ensured by single or double bilayer membranes that separate the cell from the exterior and form boundaries between the cell's organelles and the cytosol. Nascent nuclear envelopes and autophagosomes, which both are enveloped by double membranes, need to be sealed during the late stage of their biogenesis. On the other hand, the integrity of cellular membranes such as the plasma membrane, lysosomes and the nuclear envelope can be compromised by pathogens, chemicals, radiation, inflammatory responses and mechanical stress. There are cellular programmes that restore membrane integrity after injury. Here, we review cellular mechanisms that have evolved to maintain membrane integrity during organelle biogenesis and after injury, including membrane scission mediated by the endosomal sorting complex required for transport (ESCRT), vesicle patching and endocytosis.
Identifiants
pubmed: 33644904
doi: 10.15252/embj.2020106922
pmc: PMC8013788
doi:
Substances chimiques
Endosomal Sorting Complexes Required for Transport
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e106922Informations de copyright
© 2021 The Authors. Published under the terms of the CC BY NC ND 4.0 license.
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