Rationale and Design of the Awake Prone Position for Early Hypoxemia in COVID-19 Study Protocol: A Clinical Trial.
Bayesian analysis
COVID-19
prone position
Journal
Annals of the American Thoracic Society
ISSN: 2325-6621
Titre abrégé: Ann Am Thorac Soc
Pays: United States
ID NLM: 101600811
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
pubmed:
2
3
2021
medline:
7
9
2021
entrez:
1
3
2021
Statut:
ppublish
Résumé
The unprecedented public health burdens of coronavirus disease (COVID-19) have intensified the urgency of identifying effective, low-cost treatments that limit the need for advanced life support measures and improve clinical outcomes. However, personal protective equipment and staffing shortages, disease virulence, and infectivity have created significant barriers to traditional clinical trial practices. We present the novel design of a pragmatic, adaptive, multicenter, international, prospective randomized controlled clinical trial evaluating the safety and effectiveness of awake prone positioning in spontaneously breathing patients with COVID-19 (APPEX-19 [Awake Prone Position for Early Hypoxemia in COVID-19]). Key innovations of this trial include
Identifiants
pubmed: 33647225
doi: 10.1513/AnnalsATS.202009-1124SD
pmc: PMC8489858
doi:
Banques de données
ClinicalTrials.gov
['NCT04344587']
Types de publication
Clinical Trial Protocol
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1560-1566Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL007035
Pays : United States
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