Corneal neurotization for neurotrophic keratopathy: Review of surgical techniques and outcomes.

Anesthetic cornea Corneal nerve Herpetic keratopathy Nerve coaptation Neurotization Neurotrophic cornea Neurotrophic keratopathy

Journal

The ocular surface
ISSN: 1937-5913
Titre abrégé: Ocul Surf
Pays: United States
ID NLM: 101156063

Informations de publication

Date de publication:
04 2021
Historique:
received: 11 12 2020
revised: 18 02 2021
accepted: 22 02 2021
pubmed: 2 3 2021
medline: 6 7 2021
entrez: 1 3 2021
Statut: ppublish

Résumé

Neurotrophic keratopathy is a degenerative disease in which damage to the corneal nerves leads to corneal hypoesthesia. Injuries to neurotrophic corneas are notoriously difficult to treat and have traditionally been approached with supportive management. However, recent progress in the field of corneal neurotization has given new direction for addressing nerve loss directly by stimulating new nerve growth onto the cornea from nearby sensory nerves transferred to the perilimbal region. Herein, we review the surgical techniques utilized in corneal neurotization, including direct transfers and the use of nerve grafts. Considerations in surgical approach, as well as factors that influence prognosis and outcomes of the surgical intervention are also discussed.

Identifiants

pubmed: 33647470
pii: S1542-0124(21)00010-0
doi: 10.1016/j.jtos.2021.02.010
pmc: PMC8113161
mid: NIHMS1679575
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

163-172

Subventions

Organisme : NEI NIH HHS
ID : P30 EY001792
Pays : United States

Informations de copyright

Copyright © 2021. Published by Elsevier Inc.

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Auteurs

Catherine Y Liu (CY)

Viterbi Family Department of Ophthalmology, UC San Diego, San Diego, CA, USA. Electronic address: yul107@health.ucsd.edu.

Andrea C Arteaga (AC)

Illinois Eye and Ear Infirmary, Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.

Sammie E Fung (SE)

Viterbi Family Department of Ophthalmology, UC San Diego, San Diego, CA, USA.

M Soledad Cortina (MS)

Illinois Eye and Ear Infirmary, Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.

Ilya M Leyngold (IM)

Duke University Medical Center, Department of Ophthalmology, Durham, NC, USA.

Vinay K Aakalu (VK)

Illinois Eye and Ear Infirmary, Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.

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