The pulse: transient fMRI signal increases in subcortical arousal systems during transitions in attention.
Adolescent
Adult
Arousal
/ physiology
Attention
/ physiology
Child
Cohort Studies
Female
Gyrus Cinguli
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
/ methods
Male
Nerve Net
/ diagnostic imaging
Photic Stimulation
/ methods
Psychomotor Performance
/ physiology
Thalamus
/ diagnostic imaging
Young Adult
Arousal
Attention
Consciousness
Midbrain
Thalamus
fMRI
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 05 2021
15 05 2021
Historique:
received:
20
08
2020
revised:
02
02
2021
accepted:
12
02
2021
pubmed:
2
3
2021
medline:
15
10
2021
entrez:
1
3
2021
Statut:
ppublish
Résumé
Studies of attention emphasize cortical circuits for salience monitoring and top-down control. However, subcortical arousal systems have a major influence on dynamic cortical state. We hypothesize that task-related increases in attention begin with a "pulse" in subcortical arousal and cortical attention networks, which are reflected indirectly through transient fMRI signals. We conducted general linear model and model-free analyses of fMRI data from two cohorts and tasks with mixed block and event-related design. 46 adolescent subjects at our center and 362 normal adults from the Human Connectome Project participated. We identified a core shared network of transient fMRI increases in subcortical arousal and cortical salience/attention networks across cohorts and tasks. Specifically, we observed a transient pulse of fMRI increases both at task block onset and with individual task events in subcortical arousal areas including midbrain tegmentum, thalamus, nucleus basalis and striatum; cortical-subcortical salience network regions including the anterior insula/claustrum and anterior cingulate cortex/supplementary motor area; in dorsal attention network regions including dorsolateral frontal cortex and inferior parietal lobule; as well as in motor regions including cerebellum, and left hemisphere hand primary motor cortex. The transient pulse of fMRI increases in subcortical and cortical arousal and attention networks was consistent across tasks and study populations, whereas sustained activity in these same networks was more variable. The function of the transient pulse in these networks is unknown. However, given its anatomical distribution, it could participate in a neuromodulatory surge of activity in multiple parallel neurotransmitter systems facilitating dynamic changes in conscious attention.
Identifiants
pubmed: 33647499
pii: S1053-8119(21)00150-6
doi: 10.1016/j.neuroimage.2021.117873
pmc: PMC8278331
mid: NIHMS1711270
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117873Subventions
Organisme : NINDS NIH HHS
ID : R01 NS055829
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no competing financial interests.
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