Vaccines do not cause atopic dermatitis: A systematic review and meta-analysis.
Atopic dermatitis
Immunity
Vaccine
Journal
Vaccine
ISSN: 1873-2518
Titre abrégé: Vaccine
Pays: Netherlands
ID NLM: 8406899
Informations de publication
Date de publication:
26 03 2021
26 03 2021
Historique:
received:
12
10
2020
revised:
11
02
2021
accepted:
13
02
2021
pubmed:
3
3
2021
medline:
25
5
2021
entrez:
2
3
2021
Statut:
ppublish
Résumé
Previous studies found conflicting results about the association of vaccinations and likelihood of atopic dermatitis (AD). To determine whether vaccinations increase the likelihood of AD. A systematic review was performed of all published studies in MEDLINE, EMBASE, LILACS, Scopus, and Web of Science databases. At least 2 reviewers conducted title/abstract, full-text review, and data extraction. Quality of evidence was assessed using the Newcastle-Ottawa Scale (NOS). Forty-four studies met inclusion criteria; 37 had sufficient data for meta-analysis. There were no associations any vaccine regimen (random-effects logistic regression: odds ratio [95% confidence interval]: 0.961 [0.822-1.124]; n = 21 studies) BCG (0.927 [0.701-1.226]; n = 8), pertussis (0.790 [0.416-1.499]; n = 4), single (1.031 [0.920-1.155]; n = 17) or multiple vaccines (0.902 [0.608-1.338]; n = 7) with likelihood of AD. This remained true in studies with high-quality (NOS ≥ 7) (OR [95% CI]: 0.941 [0.793-1.117]; n = 13 studies) or low-quality (NOS < 7) (OR [95% CI]: 1.058 [0.669-1.674]; n = 8 studies). No randomized controlled trials. No vaccine regimen was consistently associated with developing AD.
Sections du résumé
BACKGROUND
Previous studies found conflicting results about the association of vaccinations and likelihood of atopic dermatitis (AD).
OBJECTIVES
To determine whether vaccinations increase the likelihood of AD.
METHODS
A systematic review was performed of all published studies in MEDLINE, EMBASE, LILACS, Scopus, and Web of Science databases. At least 2 reviewers conducted title/abstract, full-text review, and data extraction. Quality of evidence was assessed using the Newcastle-Ottawa Scale (NOS).
RESULTS
Forty-four studies met inclusion criteria; 37 had sufficient data for meta-analysis. There were no associations any vaccine regimen (random-effects logistic regression: odds ratio [95% confidence interval]: 0.961 [0.822-1.124]; n = 21 studies) BCG (0.927 [0.701-1.226]; n = 8), pertussis (0.790 [0.416-1.499]; n = 4), single (1.031 [0.920-1.155]; n = 17) or multiple vaccines (0.902 [0.608-1.338]; n = 7) with likelihood of AD. This remained true in studies with high-quality (NOS ≥ 7) (OR [95% CI]: 0.941 [0.793-1.117]; n = 13 studies) or low-quality (NOS < 7) (OR [95% CI]: 1.058 [0.669-1.674]; n = 8 studies).
LIMITATIONS
No randomized controlled trials.
CONCLUSIONS
No vaccine regimen was consistently associated with developing AD.
Identifiants
pubmed: 33648762
pii: S0264-410X(21)00203-6
doi: 10.1016/j.vaccine.2021.02.036
pii:
doi:
Substances chimiques
Vaccines
0
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1805-1811Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.