Premalignant pancreatic cells seed stealth metastasis in distant organs in mice.
Animals
Bone Marrow
/ pathology
Carcinogenesis
/ genetics
Cell Lineage
/ genetics
Disease Models, Animal
Homeodomain Proteins
/ genetics
Humans
Liver
/ pathology
Lung
/ pathology
Mice
Neoplasm Metastasis
/ genetics
Pancreas
/ metabolism
Precancerous Conditions
/ genetics
Proto-Oncogene Proteins p21(ras)
/ genetics
Trans-Activators
/ genetics
Trefoil Factor-1
/ genetics
Tumor Suppressor Protein p53
/ genetics
Journal
Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
29
10
2020
accepted:
08
02
2021
revised:
28
01
2021
pubmed:
3
3
2021
medline:
15
10
2021
entrez:
2
3
2021
Statut:
ppublish
Résumé
Recent findings suggest that the dissemination of tumor cells occurs at the early stage of breast and pancreatic carcinogenesis, which is known as early dissemination. The evidence of early dissemination has been demonstrated predominantly in the bloodstream and bone marrow; however, limited evidence has revealed the existence and behavior of disseminated cells in distant organs. Here, we show that premalignant pancreatic cells seed distant stealth metastasis that eventually develops into manifest metastasis. By analyzing lineage-labeled pancreatic cancer mouse models (KPCT/TFF1KO; Pdx1-Cre/LSL-KRAS
Identifiants
pubmed: 33649537
doi: 10.1038/s41388-021-01706-8
pii: 10.1038/s41388-021-01706-8
doi:
Substances chimiques
Homeodomain Proteins
0
Tff1 protein, mouse
0
Trans-Activators
0
Trefoil Factor-1
0
Trp53 protein, mouse
0
Tumor Suppressor Protein p53
0
pancreatic and duodenal homeobox 1 protein
0
Hras protein, mouse
EC 3.6.5.2
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2273-2284Références
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