Endolysosomal Disorders Affecting the Proximal Tubule of the Kidney: New Mechanistic Insights and Therapeutics.
Autophagy
Cell differentiation
Endolysosomal diseases
Endolysosome
Membrane trafficking
Receptor-mediated endocytosis
Journal
Reviews of physiology, biochemistry and pharmacology
ISSN: 0303-4240
Titre abrégé: Rev Physiol Biochem Pharmacol
Pays: Germany
ID NLM: 0434624
Informations de publication
Date de publication:
2023
2023
Historique:
pubmed:
3
3
2021
medline:
1
2
2023
entrez:
2
3
2021
Statut:
ppublish
Résumé
Epithelial cells that line the proximal tubule of the kidney rely on an intertwined ecosystem of vesicular membrane trafficking pathways to ensure the reabsorption of essential nutrients. To function effectively and to achieve homeostasis, these specialized cells require the sorting and recycling of a wide array of cell surface proteins within the endolysosomal network, including signaling receptors, nutrient transporters, ion channels, and polarity markers. The dysregulation of the endolysosomal system can lead to a generalized proximal tubule dysfunction, ultimately causing severe metabolic complications and kidney disease.In this chapter, we highlight the biological functions of the genes that code endolysosomal proteins from the perspective of understanding - and potentially reversing - the pathophysiology of endolysosomal disorders affecting the proximal tubule of the kidney. These insights might ultimately lead to potential treatments for currently intractable diseases and transform our ability to regulate kidney homeostasis and health.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
233-257Informations de copyright
© 2021. Springer Nature Switzerland AG.
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