Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells.
Antineoplastic Agents
/ metabolism
Biotransformation
Cell Line, Tumor
Cell Proliferation
/ drug effects
Energy Metabolism
/ drug effects
Humans
Melanoma
/ drug therapy
Melatonin
/ metabolism
Membrane Potential, Mitochondrial
/ drug effects
Mitochondria
/ drug effects
Oxidative Stress
/ drug effects
Skin Neoplasms
/ drug therapy
extracellular acidification rate
glucose uptake
melanoma cells
metabolites of melatonin
mitochondrial function
oxygen consumption rate
transmission electron microscopy
Journal
Journal of pineal research
ISSN: 1600-079X
Titre abrégé: J Pineal Res
Pays: England
ID NLM: 8504412
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
revised:
19
02
2021
received:
27
08
2020
accepted:
23
02
2021
pubmed:
3
3
2021
medline:
11
11
2021
entrez:
2
3
2021
Statut:
ppublish
Résumé
Melanoma is a leading cause of cancer deaths worldwide. Although immunotherapy has revolutionized the treatment for some patients, resistance towards therapy and unwanted side effects remain a problem for numerous individuals. Broad anti-cancer activities of melatonin are recognized; however, additional investigations still need to be elucidated. Herein, using various human melanoma cell models, we explore in vitro the new insights into the regulation of melanoma by melatonin and its metabolites which possess, on the other side, high safety profiles and biological meaningful. In this study, using melanotic (MNT-1) and amelanotic (A375, G361, Sk-Mel-28) melanoma cell lines, the comparative oncostatic responses, the impact on melanin content (for melanotic MNT-1 melanoma cells) as well as the mitochondrial function controlled by melatonin, its precursor (serotonin), a kynuric (N
Substances chimiques
Antineoplastic Agents
0
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12728Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : KL2900/2-1
Informations de copyright
© 2021 The Authors. Journal of Pineal Research published by John Wiley & Sons Ltd.
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