Perspectives for microbeam irradiation at the SYRMEP beamline.
microbeam
microbeam irradiation
murine melanoma cells
radiotherapy
Journal
Journal of synchrotron radiation
ISSN: 1600-5775
Titre abrégé: J Synchrotron Radiat
Pays: United States
ID NLM: 9888878
Informations de publication
Date de publication:
01 Mar 2021
01 Mar 2021
Historique:
received:
27
11
2020
accepted:
12
01
2021
entrez:
2
3
2021
pubmed:
3
3
2021
medline:
29
10
2021
Statut:
ppublish
Résumé
It has been shown previously both in vitro and in vivo that microbeam irradiation (MBI) can control malignant tumour cells more effectively than the clinically established concepts of broad beam irradiation. With the aim to extend the international capacity for microbeam research, the first MBI experiment at the biomedical beamline SYRMEP of the Italian synchrotron facility ELETTRA has been conducted. Using a multislit collimator produced by the company TECOMET, arrays of quasi-parallel microbeams were successfully generated with a beam width of 50 µm and a centre-to-centre distance of 400 µm. Murine melanoma cell cultures were irradiated with a target dose of approximately 65 Gy at a mean photon energy of ∼30 keV with a dose rate of 70 Gy s
Identifiants
pubmed: 33650552
pii: S1600577521000400
doi: 10.1107/S1600577521000400
pmc: PMC7941286
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
410-418Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SCHU 2589/7-1.
Informations de copyright
open access.
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