Synthesis of PEG-4000-co-poly (AMPS) nanogels by cross-linking polymerization as highly responsive networks for enhancement in meloxicam solubility.
Nanogels
PEG-4000
cytotoxicity evaluation
meloxicam
solubility enhancement
Journal
Drug development and industrial pharmacy
ISSN: 1520-5762
Titre abrégé: Drug Dev Ind Pharm
Pays: England
ID NLM: 7802620
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
pubmed:
3
3
2021
medline:
28
4
2021
entrez:
2
3
2021
Statut:
ppublish
Résumé
Poor solubility is an ongoing issue and the graph of poorly soluble drugs has increased markedly which critically affect their dissolution, bioavailability, and clinical effects. This common issue needs to be addressed, for this purpose a series of polyethylene glycol (PEG-4000) based nanogels were developed by free radical polymerization technique to enhance the solubility, dissolution, and bioavailability of poorly soluble drug meloxicam (MLX), as improved solubility is the significant application of nanosystems. Developed nanogels formulations were characterized by FTIR, XRD, SEM, zeta sizer, percent equilibrium swelling, drug loaded content (DLC), drug entrapment efficiency (DEE), solubility studies, and
Identifiants
pubmed: 33651645
doi: 10.1080/03639045.2021.1892738
doi:
Substances chimiques
Nanogels
0
Polyethylene Glycols
3WJQ0SDW1A
Meloxicam
VG2QF83CGL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM