Shanpanootols A-F, diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activities.
Antineoplastic Agents, Phytogenic
/ isolation & purification
Diterpenes
/ isolation & purification
Gene Products, vpr
/ antagonists & inhibitors
HeLa Cells
Humans
Molecular Structure
Myanmar
Phytochemicals
/ isolation & purification
Plant Extracts
/ pharmacology
Rhizome
/ chemistry
Zingiberaceae
/ chemistry
Isopimarane diterpenoid
Kaempferia pulchra
Myanmar
Shanpanootols
Vpr
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
05
02
2021
revised:
22
02
2021
accepted:
23
02
2021
pubmed:
3
3
2021
medline:
18
9
2021
entrez:
2
3
2021
Statut:
ppublish
Résumé
Six new isopimarane diterpenoids, shanpanootols A-F (1-6), along with two known analogues, were isolated from the ethyl acetate-soluble extract of Kaempferia pulchra rhizomes collected in Myanmar. The structures of these compounds were elucidated by extensive spectroscopic techniques such as 1D and 2D NMR and HRESIMS. The absolute configuration of 1 was determined by the modified Mosher method. The new isolates (1-6) were tested for their Vpr inhibitory activities against TREx-HeLa-Vpr cells. Shanpanootols C (3) and E (5) inhibited Vpr at doses of 2.5 and 5 μM, respectively.
Identifiants
pubmed: 33652075
pii: S0367-326X(21)00045-9
doi: 10.1016/j.fitote.2021.104870
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Diterpenes
0
Gene Products, vpr
0
Phytochemicals
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104870Informations de copyright
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