Recognition of food antigens by the mucosal and systemic immune system: Consequences for intestinal development and homeostasis.
Apoptosis
Crohn’s disease
Food antigens
Inflammation
Peyer’s patches
Journal
International journal of medical microbiology : IJMM
ISSN: 1618-0607
Titre abrégé: Int J Med Microbiol
Pays: Germany
ID NLM: 100898849
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
18
08
2020
revised:
19
02
2021
accepted:
23
02
2021
pubmed:
3
3
2021
medline:
15
5
2021
entrez:
2
3
2021
Statut:
ppublish
Résumé
The impact of nutrition on systemic and intestinal immune responses remains controversially discussed and yet not fully understood. The majority of studies investigating the effects of dietary antigens focused to understand how local and systemic unresponsiveness is induced by innocuous food antigens. Moreover, it has been shown that both, microbial and dietary antigens are essential for the normal development of the mucosal immune system. Based on experimental findings from animals and IBD patients, we propose a model how the intestinal immune system performs the balancing act between recognition and tolerance of dietary antigens at the same time: In the healthy gut, repetitive uptake of dietary antigens by Peyer's patches leads to increasing activation of CD4
Identifiants
pubmed: 33652373
pii: S1438-4221(21)00022-9
doi: 10.1016/j.ijmm.2021.151493
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
151493Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier GmbH.. All rights reserved.