Prenatal Biochemical and Ultrasound Markers in COVID-19 Pregnant Patients: A Prospective Case-Control Study.
COVID-19
SARS-CoV-2
fetal congenital anomalies
fetus
first trimester
nuchal translucency
prenatal screening test
vertical transmission
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
26 Feb 2021
26 Feb 2021
Historique:
received:
29
12
2020
revised:
19
02
2021
accepted:
22
02
2021
entrez:
3
3
2021
pubmed:
4
3
2021
medline:
4
3
2021
Statut:
epublish
Résumé
This prospective observational study aimed to evaluate whether women with SARS-CoV-2 infection during the first trimester of pregnancy are at higher risk of noninvasive prenatal screening test alterations and/or of congenital fetal anomalies at the second-trimester fetal anatomy scan. Maternal symptoms were secondly investigated. The study was carried out on 12-week pregnant women admitted for noninvasive prenatal testing (16 April and 22 June 2020). The cohort had seromolecular tests for SARS-CoV-2, after which they were divided into a positive case group and a negative control group. Both groups had 20-week ultrasound screening. Seventeen out of the 164 women tested positive for SARS-CoV-2 (10.3%). There were no significant differences in mean nuchal translucency thickness or biochemical markers (pregnancy-associated plasma protein A, alpha-fetoprotein, human chorionic gonadotropin, unconjugated estriol) between cases and controls (
Identifiants
pubmed: 33652805
pii: diagnostics11030398
doi: 10.3390/diagnostics11030398
pmc: PMC7996827
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Università degli Studi di Torino
ID : --
Références
J Clin Microbiol. 2020 May 26;58(6):
pubmed: 32277023
Lancet. 2020 Aug 22;396(10250):530-531
pubmed: 32771084
Birth Defects Res. 2017 Mar 15;109(5):353-362
pubmed: 28398679
Eur J Clin Microbiol Infect Dis. 2008 Sep;27(9):863-6
pubmed: 18373106
Ultrasound Obstet Gynecol. 2021 Feb;57(2):242-247
pubmed: 32798244
J Med Virol. 2021 Jan;93(1):537-540
pubmed: 32633869
Ultrasound Obstet Gynecol. 2021 Feb;57(2):232-241
pubmed: 32926494
Am J Obstet Gynecol. 2020 May;222(5):415-426
pubmed: 32105680
Nat Med. 2020 Jul;26(7):1037-1040
pubmed: 32393804
Eur J Obstet Gynecol Reprod Biol. 2020 Jun;249:98-99
pubmed: 32327266
Lancet. 2014 Sep 6;384(9946):869-79
pubmed: 25209488
Arch Pathol Lab Med. 2017 Jan;141(1):26-32
pubmed: 27636525
N Engl J Med. 1999 Aug 12;341(7):461-7
pubmed: 10441601
Virol Sin. 2020 Jun;35(3):290-304
pubmed: 32607866
Open Biol. 2020 Aug;10(8):200162
pubmed: 32750256
Trans R Soc Trop Med Hyg. 2000 Jan-Feb;94(1):1-2
pubmed: 10748883
Am J Obstet Gynecol. 2021 Apr;224(4):391.e1-391.e7
pubmed: 33039396
Clin Microbiol Infect. 2020 Dec;26(12):1690.e1-1690.e4
pubmed: 32898715
Ultrasound Obstet Gynecol. 2020 Jun;55(6):863-870
pubmed: 32233049
Hum Reprod. 2021 Jan 1;36(1):40-47
pubmed: 33145598
Nat Rev Immunol. 2020 Jun;20(6):339-341
pubmed: 32317716
Am J Obstet Gynecol. 2021 Jan;224(1):35-53.e3
pubmed: 32739398
Clin Transl Immunology. 2020 Sep 26;9(9):e1182
pubmed: 33005417
Nature. 2018 Nov;563(7731):337-338
pubmed: 30429561
Am J Obstet Gynecol. 2020 Oct;223(4):612
pubmed: 32531218
J Am Heart Assoc. 2019 May 7;8(9):e011264
pubmed: 30995883
Case Rep Obstet Gynecol. 2019 Jul 7;2019:3259760
pubmed: 31360565
PLoS One. 2020 Dec 10;15(12):e0238409
pubmed: 33301498
Elife. 2020 Jul 14;9:
pubmed: 32662421
Eur J Obstet Gynecol Reprod Biol. 2020 Jul;250:246-249
pubmed: 32418711