Perfluoroalkyl Acid Binding with Peroxisome Proliferator-Activated Receptors α, γ, and δ, and Fatty Acid Binding Proteins by Equilibrium Dialysis with a Comparison of Methods.
equilibrium dialysis
equilibrium dissociation constants
fatty acid-binding proteins
per- and polyfluorinated alkyl substances
peroxisome proliferator-activated receptors
Journal
Toxics
ISSN: 2305-6304
Titre abrégé: Toxics
Pays: Switzerland
ID NLM: 101639637
Informations de publication
Date de publication:
26 Feb 2021
26 Feb 2021
Historique:
received:
26
01
2021
revised:
13
02
2021
accepted:
19
02
2021
entrez:
3
3
2021
pubmed:
4
3
2021
medline:
4
3
2021
Statut:
epublish
Résumé
The biological impacts of per- and polyfluorinated alkyl substances (PFAS) are linked to their protein interactions. Existing research has largely focused on serum albumin and liver fatty acid binding protein, and binding affinities determined with a variety of methods show high variability. Moreover, few data exist for short-chain PFAS, though their prevalence in the environment is increasing. We used molecular dynamics (MD) to screen PFAS binding to liver and intestinal fatty acid binding proteins (L- and I-FABPs) and peroxisome proliferator activated nuclear receptors (PPAR-α, -δ and -γ) with six perfluoroalkyl carboxylates (PFCAs) and three perfluoroalkyl sulfonates (PFSAs). Equilibrium dissociation constants, K
Identifiants
pubmed: 33652875
pii: toxics9030045
doi: 10.3390/toxics9030045
pmc: PMC7996760
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Strategic Environmental Research and Development Program
ID : ER-181417
Références
Environ Pollut. 2011 Jan;159(1):169-174
pubmed: 20932617
Environ Sci Technol. 2013 May 7;47(9):4164-71
pubmed: 23566120
J Cheminform. 2012 Aug 13;4(1):17
pubmed: 22889332
Int J Hyg Environ Health. 2012 Feb;215(2):212-5
pubmed: 22001330
Environ Sci Technol. 2006 Jan 1;40(1):32-44
pubmed: 16433330
PLoS One. 2012;7(5):e33643
pubmed: 22606221
Environ Sci Technol. 2019 Feb 19;53(4):2181-2188
pubmed: 30649875
Nat Rev Drug Discov. 2008 Jun;7(6):489-503
pubmed: 18511927
Arch Pediatr Adolesc Med. 2010 Sep;164(9):860-9
pubmed: 20819969
Annu Rev Cell Dev Biol. 1996;12:335-63
pubmed: 8970730
Ecotoxicol Environ Saf. 2013 Oct;96:139-46
pubmed: 23849467
Diabetes Technol Ther. 2002;4(2):163-74
pubmed: 12079620
Curr Opin Struct Biol. 2011 Feb;21(1):50-61
pubmed: 21071205
Environ Sci Technol. 2008 Aug 15;42(16):6291-5
pubmed: 18767701
Environ Int. 2007 Aug;33(6):782-8
pubmed: 17442394
Environ Toxicol Chem. 2011 Nov;30(11):2423-30
pubmed: 21842491
Biopolymers. 2006 Jun 15;82(3):261-71
pubmed: 16506168
Environ Health Perspect. 2009 Jun;117(6):923-7
pubmed: 19590684
J Biol Chem. 2012 Jan 2;287(1):183-195
pubmed: 22039047
Environ Health Perspect. 2013 Oct;121(10):1207-13
pubmed: 23838280
Chem Res Toxicol. 2003 Jun;16(6):775-81
pubmed: 12807361
Environ Sci Technol. 2016 Apr 5;50(7):3352-61
pubmed: 26894610
Environ Int. 2017 Sep;106:135-143
pubmed: 28645013
Environ Sci Technol. 2013 Aug 6;47(15):8187-95
pubmed: 23886337
Environ Sci Technol. 2013 May 21;47(10):5226-34
pubmed: 23590254
Mol Biol Cell. 2010 Dec;21(23):4061-7
pubmed: 21115850
Int J Hyg Environ Health. 2013 Nov;216(6):633-40
pubmed: 22999890
Environ Sci Technol. 2015 Jul 07;49(13):7648-56
pubmed: 26055930
Environ Pollut. 2010 May;158(5):1237-44
pubmed: 20185214
Curr Protoc Neurosci. 2010 Jul;Chapter 7:Unit 7.5
pubmed: 20578035
Environ Toxicol Chem. 2010 Aug;29(8):1669-77
pubmed: 20821618
Environ Sci Technol. 2008 Feb 15;42(4):995-1003
pubmed: 18351063
Mol Cell Biol. 1995 Jun;15(6):3012-22
pubmed: 7539101
Int J Hyg Environ Health. 2017 Apr;220(2 Pt B):455-460
pubmed: 28073630
J Biol Chem. 2011 Sep 9;286(36):31924-8
pubmed: 21757748
Arch Toxicol. 2016 Jan;90(1):217-27
pubmed: 25370009
Environ Sci Technol. 2015 May 5;49(9):5722-31
pubmed: 25826685
Environ Sci Technol. 2006 May 1;40(9):2924-9
pubmed: 16719092
Environ Sci Technol. 2005 Dec 1;39(23):9357-62
pubmed: 16382964
Toxicology. 2004 Mar 1;196(1-2):95-116
pubmed: 15036760
Integr Environ Assess Manag. 2011 Oct;7(4):513-41
pubmed: 21793199
Environ Sci Technol. 2018 Jul 17;52(14):7972-7980
pubmed: 29897239
Environ Sci Process Impacts. 2019 Nov 1;21(11):1908-1914
pubmed: 31332417
Arch Toxicol. 2018 Jan;92(1):359-369
pubmed: 28864880
Chemosphere. 2011 Feb;82(6):853-8
pubmed: 21112609
Environ Res. 2014 Aug;133:338-47
pubmed: 25019470
Toxicol In Vitro. 2020 Feb;62:104700
pubmed: 31676336
Environ Health Perspect. 2011 Sep;119(9):1227-32
pubmed: 21561829
J Biol Chem. 2007 Apr 13;282(15):11410-26
pubmed: 17261588
Environ Sci Technol. 2011 Oct 1;45(19):7962-73
pubmed: 21542574
Environ Sci Technol. 2012 Jul 3;46(13):7120-7
pubmed: 22681548
Anal Chem. 2010 Feb 1;82(3):974-81
pubmed: 20039637
Environ Sci Technol. 2013 Apr 16;47(8):3865-74
pubmed: 23484973
Environ Sci Technol. 2010 Jul 1;44(13):5263-9
pubmed: 20540534
Am J Epidemiol. 2009 Nov 15;170(10):1268-78
pubmed: 19846564
Environ Sci Technol. 2014 May 6;48(9):4637-48
pubmed: 24762048
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Feb 1;67(Pt 2):291-5
pubmed: 21301109
PLoS One. 2013 Aug 12;8(8):e72426
pubmed: 23951323
BMC Struct Biol. 2009 May 14;9:31
pubmed: 19442292
Environ Sci Technol. 2013 Apr 16;47(8):3875-82
pubmed: 23484930
Chemosphere. 2018 May;198:442-449
pubmed: 29425944
J Struct Biol. 2015 Sep;191(3):332-40
pubmed: 26185032
J Phys Chem B. 2005 Aug 18;109(32):15566-73
pubmed: 16852974
Ecotoxicol Environ Saf. 2004 May;58(1):68-76
pubmed: 15087165
Sci Total Environ. 2019 Feb 15;651(Pt 1):766-774
pubmed: 30253358
Environ Sci Technol. 2006 Apr 1;40(7):2128-34
pubmed: 16646443
Methods Appl Fluoresc. 2016 Apr 28;4(2):022001
pubmed: 28809163
Toxicology. 2002 Jul 15;176(3):175-85
pubmed: 12093614
Environ Sci Technol. 2013 Oct 1;47(19):11293-301
pubmed: 24006842
Toxicology. 2012 Mar 11;293(1-3):16-29
pubmed: 22245121
Toxicol Appl Pharmacol. 2014 Sep 15;279(3):275-283
pubmed: 24998974
Toxicol Sci. 2007 Oct;99(2):366-94
pubmed: 17519394