Emerging Applications of Ultrasound-Contrast Agents in Radiation Therapy.
Contrast-enhanced ultrasound
Micro-bubbles
Radiotherapy
Tumor hypoxia
Ultrasound
Journal
Ultrasound in medicine & biology
ISSN: 1879-291X
Titre abrégé: Ultrasound Med Biol
Pays: England
ID NLM: 0410553
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
17
11
2020
revised:
25
01
2021
accepted:
30
01
2021
pubmed:
4
3
2021
medline:
18
9
2021
entrez:
3
3
2021
Statut:
ppublish
Résumé
Radiation therapy (RT) causes DNA damage through ionization, leading to double-strand breaks. In addition, it generates reactive oxygen species (ROS), which are toxic to tumor cells and the vasculature. However, hypoxic regions in the tumor have been shown to not only decrease treatment response but also increase the likelihood of recurrence and metastasis. Ultrasound-sensitive micro-bubbles are emerging as a useful diagnostic and therapeutic tool within RT. Contrast-enhanced ultrasound (CEUS) has shown great promise in early prediction of tumor response to RT. Ultrasound-triggered micro-bubble cavitation has also been shown to induce bio-effects that can sensitize angiogenic tumor vessels to RT. Additionally, ultrasound can trigger the release of drugs from micro-bubble carriers via localized micro-bubble destruction. This approach has numerous applications in RT, including targeted oxygen delivery before radiotherapy. Furthermore, micro-bubbles can be used to locally create ROS without radiation. Sonodynamic therapy uses focused ultrasound and a sonosensitizer to selectively produce ROS in the tumor region and has been explored as a treatment option for cancer. This review summarizes emerging applications of ultrasound contrast agents in RT and ROS augmentation.
Identifiants
pubmed: 33653626
pii: S0301-5629(21)00057-0
doi: 10.1016/j.ultrasmedbio.2021.01.032
pmc: PMC8044052
mid: NIHMS1669667
pii:
doi:
Substances chimiques
Contrast Media
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1465-1474Subventions
Organisme : NCI NIH HHS
ID : R01 CA238241
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB026881
Pays : United States
Informations de copyright
Copyright © 2021 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest Dr. Eisenbrey receives grant and equipment support from GE Healthcare, equipment support from Siemens, and contrast agent support and consultancy fees from Lantheus Medical Imaging. The remaining authors have no conflicts of interest.
Références
Cancer Res. 2000 Jan 15;60(2):321-7
pubmed: 10667583
PLoS One. 2013 Dec 31;8(12):e84191
pubmed: 24391908
Acad Radiol. 2011 Nov;18(11):1341-8
pubmed: 21971256
Theranostics. 2012;2(12):1174-84
pubmed: 23382774
Clin Cardiol. 1997 Oct;20(10 Suppl 1):I7-11
pubmed: 9383596
Nanotheranostics. 2020 Feb 28;4(2):83-90
pubmed: 32190535
J Ultrasound Med. 2019 Dec;38(12):3221-3228
pubmed: 31124171
Int J Pharm. 2015 Jan 15;478(1):361-367
pubmed: 25448552
Curr Mol Med. 2009 May;9(4):442-58
pubmed: 19519402
Technol Cancer Res Treat. 2014 Oct;13(5):435-44
pubmed: 24000993
Theranostics. 2018 Jan 1;8(1):156-168
pubmed: 29290799
J Radiat Res. 2011;52(1):103-9
pubmed: 21187668
Breast Cancer Res. 2001;3(5):318-22
pubmed: 11597321
IEEE Trans Biomed Eng. 2010 Jan;57(1):24-8
pubmed: 19709952
Science. 2003 May 16;300(5622):1155-9
pubmed: 12750523
Langmuir. 2019 Aug 6;35(31):10068-10078
pubmed: 30827115
Nanotheranostics. 2019 Oct 1;3(4):331-341
pubmed: 31687321
Oncotarget. 2019 Jan 01;10(1):6-7
pubmed: 30713596
Adv Drug Deliv Rev. 2011 Jul 18;63(8):640-58
pubmed: 21514334
Sci Rep. 2018 May 22;8(1):7986
pubmed: 29789589
J Control Release. 2018 Jun 10;279:8-16
pubmed: 29653222
Adv Exp Med Biol. 2016;880:429-50
pubmed: 26486350
Ultrasound Med Biol. 2020 Jun;46(6):1296-1325
pubmed: 32165014
JHEP Rep. 2020 Apr 28;2(3):100100
pubmed: 32514496
Redox Biol. 2019 Jul;25:101084
pubmed: 30612957
Theranostics. 2020 Mar 25;10(10):4659-4675
pubmed: 32292521
J Ultrasound Med. 2020 Dec;39(12):2415-2425
pubmed: 32525248
Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):E2033-41
pubmed: 22778441
J Neurosurg. 2009 Aug;111(2):226-9
pubmed: 19326986
Adv Healthc Mater. 2020 May;9(9):e1901721
pubmed: 32207250
Ultrasound Med Biol. 2014 Sep;40(9):2125-33
pubmed: 25023114
Sci Transl Med. 2012 Jun 27;4(140):140ra88
pubmed: 22745438
Radiology. 2021 Feb;298(2):450-457
pubmed: 33320067
Eur J Nucl Med Mol Imaging. 2010 Aug;37 Suppl 1:S138-46
pubmed: 20461376
J Pharm Pharmacol. 2004 Jan;56(1):85-90
pubmed: 14980005
Oncoscience. 2016 Mar 24;3(3-4):98-108
pubmed: 27226983
Integr Cancer Ther. 2009 Sep;8(3):283-7
pubmed: 19815599
Cancer Lett. 2017 Dec 28;411:100-105
pubmed: 28969964
Int J Radiat Oncol Biol Phys. 1984 May;10(5):695-712
pubmed: 6735758
Tumour Biol. 2016 Aug;37(8):10415-26
pubmed: 26846106
Ultrasound Med Biol. 2012 Jul;38(7):1212-21
pubmed: 22579547
Photoacoustics. 2020 Jul 25;20:100201
pubmed: 32775198
J Biomed Nanotechnol. 2015 Feb;11(2):274-81
pubmed: 26349303
PLoS One. 2017 Jul 26;12(7):e0181951
pubmed: 28746357
Ultrason Sonochem. 2016 Sep;32:158-164
pubmed: 27150756
Cancer Sci. 2007 Jun;98(6):916-20
pubmed: 17419708
Chem Commun (Camb). 2012 Aug 28;48(67):8332-4
pubmed: 22790600
Ultrason Sonochem. 2016 Jul;31:437-48
pubmed: 26964970
Dis Model Mech. 2014 Mar;7(3):363-72
pubmed: 24487407
Int J Hyperthermia. 2003 Sep-Oct;19(5):507-19
pubmed: 12944166
J Natl Cancer Inst. 2018 Sep 1;110(9):1009-1018
pubmed: 29506145
Ann N Y Acad Sci. 2000;899:335-48
pubmed: 10863551
Nat Rev Cancer. 2004 Jun;4(6):437-47
pubmed: 15170446
Drug Des Devel Ther. 2013 May 03;7:375-88
pubmed: 23667309
Acta Radiol. 2019 Jun;60(6):788-797
pubmed: 30231620
Theranostics. 2018 Jan 1;8(2):314-327
pubmed: 29290810
Angiogenesis. 2013 Apr;16(2):443-54
pubmed: 23314761
Ultrasound Med Biol. 2015 Jun;41(6):1500-17
pubmed: 25813532
PLoS One. 2018 Apr 9;13(4):e0195667
pubmed: 29630640
Technol Cancer Res Treat. 2013 Feb;12(1):53-60
pubmed: 22905807
AJR Am J Roentgenol. 2005 Feb;184(2):574-8
pubmed: 15671383
Cancer Lett. 2013 Jul 10;335(1):93-9
pubmed: 23402818
Int J Radiat Oncol Biol Phys. 2018 May 1;101(1):88-96
pubmed: 29477294
Biomed Res Int. 2015;2015:640397
pubmed: 26090430
Radiat Oncol. 2014 Dec 18;9:266
pubmed: 25518850
Biopharm Drug Dispos. 2011 Sep;32(6):319-32
pubmed: 21815170
J Control Release. 2016 Dec 10;243:172-181
pubmed: 27744037
Oncoscience. 2015 Dec 15;2(12):944-57
pubmed: 26909363
Ultrasonics. 2013 Jan;53(1):29-35
pubmed: 22560541
Biol Chem. 2015 Jun;396(6-7):645-57
pubmed: 25741736
Magn Reson Imaging Clin N Am. 2016 Feb;24(1):261-288
pubmed: 26613885
J Control Release. 2015 Apr 10;203:51-6
pubmed: 25660073
Oncogene. 2003 Sep 1;22(37):5897-906
pubmed: 12947396