Reciprocal Links between Pre-messenger RNA 3'-End Processing and Genome Stability.
DNA damage
RNA cleavage
genomic instability
polyadenylation
transcription termination
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
01
09
2020
revised:
11
01
2021
accepted:
22
01
2021
pubmed:
4
3
2021
medline:
18
9
2021
entrez:
3
3
2021
Statut:
ppublish
Résumé
The 3'-end processing of most pre-messenger RNAs (pre-mRNAs) involves RNA cleavage and polyadenylation and is coupled to transcription termination. In both yeast and human cells, pre-mRNA 3'-end cleavage is globally inhibited by DNA damage. Recently, further links between pre-mRNA 3'-end processing and the control of genome stability have been uncovered, as reviewed here. Upon DNA damage, various genes related to the DNA damage response (DDR) escape 3'-end processing inhibition or are regulated through alternative polyadenylation (APA). Conversely, various pre-mRNA 3'-end processing factors prevent genome instability and are found at sites of DNA damage. Finally, the reciprocal link between pre-mRNA 3'-end processing and genome stability control seems important because it is conserved in evolution and involved in disease development.
Identifiants
pubmed: 33653631
pii: S0968-0004(21)00023-2
doi: 10.1016/j.tibs.2021.01.009
pii:
doi:
Substances chimiques
RNA, Messenger
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
579-594Informations de copyright
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