Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19.
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
02 03 2021
02 03 2021
Historique:
received:
17
11
2020
accepted:
25
02
2021
entrez:
3
3
2021
pubmed:
4
3
2021
medline:
16
3
2021
Statut:
ppublish
Résumé
Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but rarely death. The immune features of MIS-C compared to pediatric COVID-19 or adult disease remain poorly understood. We analyzed peripheral blood immune responses in hospitalized SARS-CoV-2 infected pediatric patients (pediatric COVID-19) and patients with MIS-C. MIS-C patients had patterns of T cell-biased lymphopenia and T cell activation similar to severely ill adults, and all patients with MIS-C had SARS-CoV-2 spike-specific antibodies at admission. A distinct feature of MIS-C patients was robust activation of vascular patrolling CX3CR1+ CD8+ T cells that correlated with the use of vasoactive medication. Finally, whereas pediatric COVID-19 patients with acute respiratory distress syndrome (ARDS) had sustained immune activation, MIS-C patients displayed clinical improvement over time, concomitant with decreasing immune activation. Thus, non-MIS-C versus MIS-C SARS-CoV-2 associated illnesses are characterized by divergent immune signatures that are temporally distinct from one another and implicate CD8+ T cells in the clinical presentation and trajectory of MIS-C.
Identifiants
pubmed: 33653907
pii: 6/57/eabf7570
doi: 10.1126/sciimmunol.abf7570
pmc: PMC8128303
mid: NIHMS1697788
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007324
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : F99 CA234842
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA230157
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI082630
Pays : United States
Organisme : NCI NIH HHS
ID : K00 CA234842
Pays : United States
Organisme : NICHD NIH HHS
ID : R61 HD105594
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI121250
Pays : United States
Organisme : NIH HHS
ID : AI105343
Pays : United States
Organisme : NIH HHS
ID : HL143613
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI136660
Pays : United States
Organisme : NIH HHS
ID : AI082630
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137006
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137915
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007586
Pays : United States
Organisme : NIH HHS
ID : HL137915
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009140
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA193776
Pays : United States
Organisme : NHLBI NIH HHS
ID : R38 HL143613
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI135091
Pays : United States
Organisme : NIH HHS
ID : CA230157
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK112217
Pays : United States
Organisme : NIH HHS
ID : HL137006
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI105343
Pays : United States
Investigateurs
Sharon Adamski
(S)
Zahidul Alam
(Z)
Mary M Addison
(MM)
Katelyn T Byrne
(KT)
Aditi Chandra
(A)
Hélène C Descamps
(HC)
Nicholas Han
(N)
Yaroslav Kaminskiy
(Y)
Shane C Kammerman
(SC)
Justin Kim
(J)
Allison R Greenplate
(AR)
Jacob T Hamilton
(JT)
Nune Markosyan
(N)
Julia Han Noll
(JH)
Dalia K Omran
(DK)
Ajinkya Pattekar
(A)
Eric Perkey
(E)
Elizabeth M Prager
(EM)
Dana Pueschl
(D)
Austin Rennels
(A)
Jennifer B Shah
(JB)
Jake S Shilan
(JS)
Nils Wellhausen
(N)
Ashley N Vanderbeck
(AN)
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2021, American Association for the Advancement of Science.
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