Bacteriological Profile and Antimicrobial Susceptibility Patterns of Bloodstream Infection at Kigali University Teaching Hospital.
Rwanda
antimicrobials
bacteriological profile
bloodstream infection; BSI
Journal
Infection and drug resistance
ISSN: 1178-6973
Titre abrégé: Infect Drug Resist
Pays: New Zealand
ID NLM: 101550216
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
12
2020
accepted:
12
02
2021
entrez:
3
3
2021
pubmed:
4
3
2021
medline:
4
3
2021
Statut:
epublish
Résumé
Worldwide, bacterial bloodstream infections (BSIs) constitute an important cause of morbidity and mortality in clinical settings. Due to the limited laboratory facilities in sub-Saharan Africa, poor diagnosis of BSIs results in poor clinical outcomes and leads to a risk of antimicrobial resistance. The present work was carried out to describe the microbiological features of BSIs using the data collected from Centre Hospitalier Universitaire de Kigali (CHUK). A retrospective study was carried out at CHUK. The blood culture results of 2,910 cases - from adults, children and infants - were reviewed in the Microbiology service from October 2017 to October 2018. The following variables were considered: age, gender, admitting department, blood culture results, and antimicrobials sensitivity test results. Data were entered and analyzed using Microsoft Excel 2013. Twelve percent (341/2,910) of blood culture results reviewed were positive with 108 (31.7%) Gram positive bacteria and 233 (68.3%) Gram negative bacteria. The most prevalent pathogens were The prevalence of bacterial pathogens in BSIs was found to be high. The antibiotic resistance to the commonly used antibiotics was high. Appropriate treatment of BSIs should be based on the current knowledge of bacterial resistance pattern. This study will help in formulating management of diagnostic guidelines and antibiotic policy.
Sections du résumé
BACKGROUND
BACKGROUND
Worldwide, bacterial bloodstream infections (BSIs) constitute an important cause of morbidity and mortality in clinical settings. Due to the limited laboratory facilities in sub-Saharan Africa, poor diagnosis of BSIs results in poor clinical outcomes and leads to a risk of antimicrobial resistance. The present work was carried out to describe the microbiological features of BSIs using the data collected from Centre Hospitalier Universitaire de Kigali (CHUK).
METHODS
METHODS
A retrospective study was carried out at CHUK. The blood culture results of 2,910 cases - from adults, children and infants - were reviewed in the Microbiology service from October 2017 to October 2018. The following variables were considered: age, gender, admitting department, blood culture results, and antimicrobials sensitivity test results. Data were entered and analyzed using Microsoft Excel 2013.
RESULTS
RESULTS
Twelve percent (341/2,910) of blood culture results reviewed were positive with 108 (31.7%) Gram positive bacteria and 233 (68.3%) Gram negative bacteria. The most prevalent pathogens were
CONCLUSION
CONCLUSIONS
The prevalence of bacterial pathogens in BSIs was found to be high. The antibiotic resistance to the commonly used antibiotics was high. Appropriate treatment of BSIs should be based on the current knowledge of bacterial resistance pattern. This study will help in formulating management of diagnostic guidelines and antibiotic policy.
Identifiants
pubmed: 33654414
doi: 10.2147/IDR.S299520
pii: 299520
pmc: PMC7914060
doi:
Types de publication
Journal Article
Langues
eng
Pagination
699-707Informations de copyright
© 2021 Habyarimana et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Virulence. 2016 Apr 2;7(3):252-66
pubmed: 26984779
PLoS One. 2015 Dec 15;10(12):e0144944
pubmed: 26670718
Virulence. 2016 Apr 2;7(3):267-79
pubmed: 26760527
S Afr Med J. 2017 Aug 25;107(9):758-762
pubmed: 28875883
Infect Drug Resist. 2015 Nov 18;8:379-89
pubmed: 26604806
Infect Dis Rep. 2017 Mar 30;9(1):6849
pubmed: 28458799
Antimicrob Resist Infect Control. 2019 Dec 30;8:207
pubmed: 31893041
Lancet Infect Dis. 2010 Jun;10(6):417-32
pubmed: 20510282
Afr J Lab Med. 2016 Sep 15;5(1):432
pubmed: 28879114
Ethiop J Health Sci. 2011 Mar;21(1):1-8
pubmed: 22434980
BMC Infect Dis. 2019 Jul 11;19(1):609
pubmed: 31296179
J Infect Dis. 2000 Apr;181(4):1414-20
pubmed: 10762572
BMC Res Notes. 2015 Jul 03;8:289
pubmed: 26138060
J Clin Microbiol. 2016 Jun;54(6):1418-1424
pubmed: 26818669
Am J Infect Control. 2018 Dec;46(12):e75-e79
pubmed: 30172607
BMJ Open. 2017 Mar 21;7(3):e013665
pubmed: 28325858
Springerplus. 2015 Jul 03;4:314
pubmed: 26155453
Am J Public Health. 2015 Dec;105(12):2409-10
pubmed: 26469675
BMC Infect Dis. 2017 Dec 6;17(1):750
pubmed: 29207958
Virulence. 2015;6(4):316-26
pubmed: 25785541
New Microbes New Infect. 2015 Jul 16;7:100-4
pubmed: 26442153
Ann N Y Acad Sci. 2014 Sep;1323:43-55
pubmed: 24628272
Clin Infect Dis. 2015 Nov 1;61 Suppl 4:S372-9
pubmed: 26449954
PLoS One. 2015 Dec 23;10(12):e0145632
pubmed: 26700032
PLoS One. 2011;6(9):e25298
pubmed: 21966489
Microb Pathog. 2017 Jan;102:45-53
pubmed: 27856272
Ann Clin Microbiol Antimicrob. 2016 Aug 18;15(1):49
pubmed: 27539221
Int J Biol Med Res. 2015 Nov;6(1):4709-4717
pubmed: 26997847
Infect Drug Resist. 2018 Nov 15;11:2321-2333
pubmed: 30532565
Clin Microbiol Rev. 2014 Oct;27(4):647-64
pubmed: 25278570
Am J Trop Med Hyg. 2015 Apr;92(4):865-70
pubmed: 25646259
Mayo Clin Proc. 2010 Feb;85(2):139-44
pubmed: 20118389
Infect Drug Resist. 2015 Jan 29;8:7-18
pubmed: 25678805
Antimicrob Agents Chemother. 2019 Dec 20;64(1):
pubmed: 31636071
Am J Trop Med Hyg. 2011 Jun;84(6):923-8
pubmed: 21633029
Emerg Infect Dis. 2018 Jul;24(7):1204-1212
pubmed: 29912684