Screening of inhibitors against SARS-CoV-2 spike protein and their capability to block the viral entry mechanism: A viroinformatics study.
ACE2
ACE2, Angiotensin-converting enzyme 2
Antiviral drugs
COVID-19, Coronavirus Disease 2019
CoVs, Coronaviruses
In silico
MD, Molecular dynamics
MERS, Middle East respiratory syndrome coronavirus
RBD
RBD, Receptor-binding domain
RMSD, Root mean square deviation
RMSF, Root mean square fluctuation
SARS, Severe acute respiratory syndrome
SARS-CoV-2
Journal
Saudi journal of biological sciences
ISSN: 1319-562X
Titre abrégé: Saudi J Biol Sci
Pays: Saudi Arabia
ID NLM: 101543796
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
14
11
2020
revised:
18
12
2020
accepted:
19
02
2021
pubmed:
4
3
2021
medline:
4
3
2021
entrez:
3
3
2021
Statut:
ppublish
Résumé
SARS-CoV-2, previously named 2019 novel coronavirus (2019-nCoV), has been associated with the global pandemic of acute respiratory distress syndrome. First reported in December 2019 in the Wuhan province of China, this new RNA virus has several folds higher transmission among humans than its other family member (SARS-CoV and MERS-CoV). The SARS-CoV-2 spike receptor-binding domain (RBD) is the region mediating the binding of the virus to host cells via Angiotensin-converting enzyme 2 (ACE2), a critical step of viral. Here in this study, we have utilized
Identifiants
pubmed: 33654454
doi: 10.1016/j.sjbs.2021.02.066
pii: S1319-562X(21)00138-8
pmc: PMC7908882
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3262-3269Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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