Calvarial Bone Implantation and
Calvaria implantation model
Osteoblastic bone metastasis
Osteolytic bone metastasis
Tumor cell implantation
Tumor microenvironment
Tumor-bone interaction
Journal
Bio-protocol
ISSN: 2331-8325
Titre abrégé: Bio Protoc
Pays: United States
ID NLM: 101635102
Informations de publication
Date de publication:
05 Feb 2019
05 Feb 2019
Historique:
received:
27
08
2018
revised:
24
12
2018
accepted:
29
01
2019
entrez:
3
3
2021
pubmed:
5
2
2019
medline:
5
2
2019
Statut:
epublish
Résumé
Bone is one of common metastasis sites for many types of cancer. In bone metastatic microenvironment, tumor-bone interactions play a significant role in the regulation of osteolytic or osteoblastic bone metastasis. In order to investigate the direct interaction between tumor cells and bone tissue, it is essential to generate appropriate animal models that mimic the behavior of tumor cells in bone metastatic lesions. Calvarial implantation model (bone invasion model) is a newly-established animal model that accurately recapitulates the behavior of tumor cells in the tumor-bone microenvironment. The surgical technique for tumor cell implantation is simpler than intracardiac, intra-arterial, or intraosseous injection techniques. This model can be useful for the identification of key factors driving tumor-induced osteolytic or osteoblastic changes.
Identifiants
pubmed: 33654960
doi: 10.21769/BioProtoc.3151
pii: e3151
pmc: PMC7854057
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e3151Informations de copyright
Copyright © 2019 The Authors; exclusive licensee Bio-protocol LLC.
Déclaration de conflit d'intérêts
Competing interestsAll authors declare no conflicts of interest.
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