7-Fluorosialyl Glycosides Are Hydrolysis Resistant but Readily Assembled by Sialyltransferases Providing Easy Access to More Metabolically Stable Glycoproteins.
Journal
ACS central science
ISSN: 2374-7943
Titre abrégé: ACS Cent Sci
Pays: United States
ID NLM: 101660035
Informations de publication
Date de publication:
24 Feb 2021
24 Feb 2021
Historique:
received:
24
11
2020
entrez:
3
3
2021
pubmed:
4
3
2021
medline:
4
3
2021
Statut:
ppublish
Résumé
The maintenance of therapeutic glycoproteins within the circulatory system is associated, in large part, with the integrity of sialic acids as terminal sugars on the glycans. Glycoprotein desialylation, either by spontaneous cleavage or through host sialidases, leads to protein clearance, mainly through the liver. Thus, the installation of minimally modified sialic acids that are hydrolysis-resistant yet biologically equivalent should lead to increased circulatory half-lives and improved pharmacokinetic profiles. Here we describe the chemoenzymatic synthesis of CMP-sialic acid sugar donors bearing fluorine atoms at the 7-position, starting from the corresponding 4-deoxy-4-fluoro-
Identifiants
pubmed: 33655072
doi: 10.1021/acscentsci.0c01589
pmc: PMC7908025
doi:
Types de publication
Journal Article
Langues
eng
Pagination
345-354Informations de copyright
© 2021 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare the following competing financial interest(s): We hold an issued patent on the technology.
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