Increased Functional Coupling between VTA and Hippocampus during Rest in First-Episode Psychosis.
hippocampus
psychosis
resting state fMRI
striatum
ventral tegmental area
Journal
eNeuro
ISSN: 2373-2822
Titre abrégé: eNeuro
Pays: United States
ID NLM: 101647362
Informations de publication
Date de publication:
Historique:
received:
25
08
2020
revised:
16
02
2021
accepted:
17
02
2021
pubmed:
5
3
2021
medline:
22
6
2021
entrez:
4
3
2021
Statut:
epublish
Résumé
Animal models suggest that interactions between the hippocampus and ventral tegmental area (VTA) underlie the onset and etiology of psychosis. While a large body of research has separately characterized alterations in hippocampal and VTA function in psychosis, alterations across the VTA and hippocampus have not been characterized in first-episode psychosis (FEP). As the phase of psychosis most proximal to conversion, studies specifically focused on FEP are valuable to psychosis research. Here, we characterize alterations in VTA-hippocampal interactions across male and female human participants experiencing their first episode of psychosis using resting state functional magnetic resonance imaging (rsfMRI). In comparison to age and sex matched healthy controls (HCs), FEP individuals had significantly greater VTA-hippocampal functional coupling but significantly less VTA-striatal functional coupling. Further, increased VTA-hippocampal functional coupling in FEP correlated with individual differences in psychosis-related symptoms. Together, these findings demonstrate alterations in mesolimbic-hippocampal circuits in FEP and extend prominent animal models of psychosis.
Identifiants
pubmed: 33658310
pii: ENEURO.0375-20.2021
doi: 10.1523/ENEURO.0375-20.2021
pmc: PMC7986546
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIMH NIH HHS
ID : K01 MH111991
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH112774
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH103204
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA043568
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 Gregory et al.
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