People with HIV-1 demonstrate type 1 interferon refractoriness associated with upregulated USP18.
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
26 04 2021
26 04 2021
Historique:
entrez:
4
3
2021
pubmed:
5
3
2021
medline:
5
3
2021
Statut:
ppublish
Résumé
HIV-1 infection persists in humans despite expression of antiviral type 1 interferons (IFN). Even exogenous administration of IFNα only marginally reduces HIV-1 abundance, raising the hypothesis that people living with HIV-1 (PLWH) are refractory to type 1 IFN. We demonstrated type 1 IFN refractoriness in CD4+ and CD8+ T cells isolated from HIV-1 infected persons by detecting diminished STAT1 phosphorylation (pSTAT1) and interferon-stimulated gene (ISG) induction upon type 1 IFN stimulation compared to healthy controls. Importantly, HIV-1 infected people who were virologically suppressed with antiretrovirals also showed type 1 IFN refractoriness. We found that USP18 levels were elevated in people with refractory pSTAT1 and ISG induction and confirmed this finding
Identifiants
pubmed: 33658340
pii: JVI.01777-20
doi: 10.1128/JVI.01777-20
pmc: PMC8139647
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDA NIH HHS
ID : U01 DA036297
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI140789
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007309
Pays : United States
Organisme : NIDA NIH HHS
ID : R37 DA013806
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI094189
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA016078
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI116868
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI108403
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI088791
Pays : United States
Informations de copyright
Copyright © 2021 American Society for Microbiology.
Références
Nature. 2013 Oct 24;502(7472):559-62
pubmed: 24048477
J Virol. 2018 Sep 26;92(20):
pubmed: 30068654
Annu Rev Immunol. 2005;23:275-306
pubmed: 15771572
Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1440-5
pubmed: 16434471
JAMA. 2004 Dec 15;292(23):2839-48
pubmed: 15598915
AIDS. 2004 Sep 3;18(13):F27-36
pubmed: 15316335
Front Microbiol. 2019 Mar 12;10:429
pubmed: 30915053
Clin Infect Dis. 2014 Nov 1;59(9):1312-21
pubmed: 25073894
Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3879-84
pubmed: 18332425
Nat Rev Microbiol. 2015 Aug;13(8):471-83
pubmed: 26179359
Clin Infect Dis. 2016 Dec 7;64(5):589-596
pubmed: 27927859
Mol Cell Biol. 2009 Sep;29(17):4841-51
pubmed: 19564419
J Acquir Immune Defic Syndr. 2009 Dec;52(5):611-22
pubmed: 19770804
J Mol Biol. 2014 Mar 20;426(6):1161-77
pubmed: 24326250
Cell Host Microbe. 2017 Apr 12;21(4):494-506.e4
pubmed: 28407485
J Med Primatol. 2008 Feb;37(1):26-30
pubmed: 18199069
J Virol. 2004 Feb;78(4):1718-29
pubmed: 14747537
J Virol. 2012 Aug;86(16):8499-506
pubmed: 22647704
Sci Adv. 2018 Aug 01;4(8):eaat0843
pubmed: 30083606
PLoS One. 2014 Feb 12;9(2):e87872
pubmed: 24533061
PLoS Pathog. 2013;9(8):e1003597
pubmed: 24009514
Nature. 2014 Jul 31;511(7511):601-5
pubmed: 25043006
Virology. 2008 Mar 30;373(1):85-97
pubmed: 18082865
EMBO Mol Med. 2015 Mar 11;7(4):464-76
pubmed: 25762615
Lancet. 1988 Nov 26;2(8622):1218-22
pubmed: 2903954
Front Immunol. 2015 Aug 19;6:426
pubmed: 26347747
AIDS Res Hum Retroviruses. 2019 Jan;35(1):25-32
pubmed: 29999412
N Engl J Med. 2004 Jul 29;351(5):451-9
pubmed: 15282352
J Virol. 2012 Aug;86(16):8367-74
pubmed: 22593165
Nature. 1997 Jun 26;387(6636):917-21
pubmed: 9202125
AIDS Res Hum Retroviruses. 2009 Jun;25(6):577-81
pubmed: 19500019
Nat Rev Microbiol. 2015 Jul;13(7):403-13
pubmed: 25915633
J Infect Dis. 2010 Jun 1;201(11):1686-96
pubmed: 20420510
J Virol. 2010 Aug;84(15):7886-91
pubmed: 20484518
J Virol. 2009 Oct;83(20):10395-405
pubmed: 19706707
J Virol. 2018 Apr 13;92(9):
pubmed: 29467313
PLoS One. 2012;7(1):e30306
pubmed: 22291932
AIDS. 2016 Aug 24;30(13):2033-42
pubmed: 27191978
Proc Natl Acad Sci U S A. 2010 May 25;107(21):9837-42
pubmed: 20457920
N Engl J Med. 2004 Jul 29;351(5):438-50
pubmed: 15282351
Hepatology. 2009 Apr;49(4):1335-74
pubmed: 19330875
Ann Intern Med. 1990 Jun 1;112(11):805-11
pubmed: 1971503
Annu Rev Med. 2008;59:473-85
pubmed: 18186707
J Leukoc Biol. 2018 Feb 13;:
pubmed: 29437254
PLoS Pathog. 2015 Nov 03;11(11):e1005254
pubmed: 26529416
J Immunol. 2007 Apr 15;178(8):5058-68
pubmed: 17404288
J Immunol. 2011 Feb 15;186(4):2106-16
pubmed: 21257970
Nature. 2008 Jan 24;451(7177):425-30
pubmed: 18200009
J Clin Invest. 2017 Dec 1;127(12):4352-4364
pubmed: 29083319
J Virol. 2017 Mar 13;91(7):
pubmed: 28100613
PLoS Pathog. 2010 Feb 26;6(2):e1000781
pubmed: 20195503
J Immunol. 2018 Mar 1;200(5):1929-1936
pubmed: 29352001
J Virol. 2008 Feb;82(4):1870-83
pubmed: 18077723
J Biol Chem. 2014 Dec 19;289(51):35102-10
pubmed: 25352594
Nat Rev Immunol. 2014 Jan;14(1):36-49
pubmed: 24362405
Nature. 2019 Feb;566(7742):120-125
pubmed: 30700913
J Interferon Cytokine Res. 2017 Dec;37(12):541-549
pubmed: 29252127
Nat Med. 1999 May;5(5):512-7
pubmed: 10229227
J Clin Invest. 2017 Jan 3;127(1):269-279
pubmed: 27941247
Gene. 2001 Apr 18;267(2):233-42
pubmed: 11313150
J Infect Dis. 2013 Jan 15;207(2):213-22
pubmed: 23105144
J Virol. 2002 May;76(9):4625-33
pubmed: 11932428
J Virol. 2019 Jan 17;93(3):
pubmed: 30404799
Hepatology. 2014 Aug;60(2):477-86
pubmed: 24706559
Cell. 1995 May 19;81(4):551-60
pubmed: 7758109
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3035-40
pubmed: 22315404
EMBO J. 2006 Jun 7;25(11):2358-67
pubmed: 16710296
J Clin Invest. 2017 Jan 3;127(1):260-268
pubmed: 27941243
PLoS One. 2012;7(1):e29291
pubmed: 22235281