Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder.
CD163
TLR4
monocytes
neuroinflammation
positron emission tomography
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
09 03 2021
09 03 2021
Historique:
entrez:
4
3
2021
pubmed:
5
3
2021
medline:
17
8
2021
Statut:
ppublish
Résumé
Synucleinopathies are neurodegenerative diseases with both central and peripheral immune responses. However, whether the peripheral immune changes occur early in disease and their relation to brain events is yet unclear. Isolated rapid-eye-movement (REM) sleep behavior disorder (iRBD) can precede synucleinopathy-related parkinsonism and provides a prodromal phenotype to study early Parkinson's disease events. In this prospective case-control study, we describe monocytic markers in a cohort of iRBD patients that were associated with the brain-imaging markers of inflammation and neuronal dysfunction. Using
Identifiants
pubmed: 33658371
pii: 2020858118
doi: 10.1073/pnas.2020858118
pmc: PMC7958435
pii:
doi:
Substances chimiques
Biomarkers
0
CD11b Antigen
0
HLA-DR Antigens
0
ITGAM protein, human
0
TLR4 protein, human
0
Toll-Like Receptor 4
0
Types de publication
Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
Competing interest statement: K.Ø. reports grants from The Danish Parkinson Association, The Danish Council for Independent Research, and the Lundbeck Foundation, and personal fees from Medtronic, UCB, Fertin Pharma, and AbbVie. D.J.B. reports grants from The Danish Council for Independent Research, the Lundbeck Foundation, The Danish Parkinson Association, European Union FP7 programme, and Alzheimer Research UK, and personal fees from GE Healthcare and Plexxikon. E.T. reports grants from The Michael J Fox Foundation and The Instituto de Salud Carlos III. N.P. reports grants from The Danish Council for Independent Research. M.R.-R. receives research support from NovoNordisk, Desiree og Niels Ydes Fond, The Danish Parkinson Association, The Danish Council for Independent Research, The Michael J Fox Foundation, and Aarhus University Research Foundation.
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