Glucocorticoid-Like Activity of Escin: A New Mechanism for an Old Drug.
clinical efficacy
escin
glucocorticoid-like activity
mechanism of action
Journal
Drug design, development and therapy
ISSN: 1177-8881
Titre abrégé: Drug Des Devel Ther
Pays: New Zealand
ID NLM: 101475745
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
12
2020
accepted:
05
02
2021
entrez:
4
3
2021
pubmed:
5
3
2021
medline:
7
10
2021
Statut:
epublish
Résumé
Saponins are a group of compounds used in clinical practice in the management of several diseases. Escin is a natural mixture of triterpene saponins which mainly consist of several isoforms, in which the α- and β-escin are predominant. β-escin is the major active compound that exerts a therapeutic effect by relieving tissue edema, promoting venous drainage, and reducing inflammation. In this review, we describe the features of its glucocorticoid-like activity that could explain its clinical effects. Using PubMed, Embase Cochrane library and reference lists for articles published until October 01, 2020, we documented that escin is likely able to exert its anti-inflammatory and anti-edematous effects through a glucocorticoid-like activity, but without the development of glucocorticoid-like adverse drug reactions.
Identifiants
pubmed: 33658760
doi: 10.2147/DDDT.S297501
pii: 297501
pmc: PMC7917317
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Escin
6805-41-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
699-704Informations de copyright
© 2021 Gallelli et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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