Serum Sodium Levels Predict Mortality in Elderly Acute Kidney Injury Patients: A Retrospective Observational Study.
acute kidney injury
elderly
mortality
serum sodium
Journal
International journal of general medicine
ISSN: 1178-7074
Titre abrégé: Int J Gen Med
Pays: New Zealand
ID NLM: 101515487
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
12
2020
accepted:
18
01
2021
entrez:
4
3
2021
pubmed:
5
3
2021
medline:
5
3
2021
Statut:
epublish
Résumé
We examined the relationship between different levels of serum sodium and mortality among elderly patients with acute kidney injury (AKI). We retrospectively enrolled elderly patients from Chinese PLA General Hospital from 2007, to 2018. All-cause mortality was examined according to eight predefined sodium levels: <130.0 mmol/L, 130.0-134.9 mmol/L, 135.0-137.9 mmol/L, 138.0-141.9 mmol/L, 142.0-144.9 mmol/L, 145.0-147.9 mmol/L, 148.0-151.9 mmol/L, and ≥152.0 mmol/L. We estimated the risk of all-cause mortality using a multivariable adjusted Cox analysis, with a normal sodium level of 135.0-137.9 mmol/L as a reference. In total, 744 patients were suitable for the final evaluation. After 90 days, the mortality rates in the eight strata were 36.1, 27.8, 19.6, 24.4, 30.7, 48.6, 52.8, and 57.7%, respectively. In the multivariable adjusted analysis, patients with sodium levels <130.0 mmol/L (HR: 2.247; 95% CI: 1.117-4.521), from 142.0 to 144.9 mmol/L (HR: 1.964; 95% CI: 1.100-3.508), from 145.0 to 147.9 mmol/L (HR: 2.942; 95% CI: 1.693-5.114), from 148.0 to 151.9 mmol/L (HR: 3.455; 95% CI: 2.009-5.944), and ≥152.0 mmol/L (HR: 3.587; 95% CI: 2.151-5.983) had an increased risk of all-cause mortality. After 1 year, the mortality rates in the eight strata were 58.3, 47.8, 33.7, 38.9, 45.5, 64.3, 69.4, and 78.4%, respectively. Patients with sodium levels <130.0 mmol/L (HR: 1.944; 95% CI: 1.125-3.360), from 142.0 to 144.9 mmol/L (HR: 1.681; 95% CI: 1.062-2.660), from 145.0 to 147.9 mmol/L (HR: 2.631; 95% CI: 1.683-4.112), from 148.0 to 151.9 mmol/L (HR: 2.411; 95% CI: 1.552-3.744), and ≥152.0 mmol/L (HR: 3.037; 95% CI: 2.021-4.563) had an increased risk of all-cause mortality. Sodium levels outside the interval of 130.0-141.9 mmol/L were associated with increased risks of 90-day mortality and 1-year mortality in elderly AKI patients.
Identifiants
pubmed: 33658833
doi: 10.2147/IJGM.S294644
pii: 294644
pmc: PMC7920587
doi:
Types de publication
Journal Article
Langues
eng
Pagination
603-612Informations de copyright
© 2021 Li et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
Sci Rep. 2017 Nov 21;7(1):15949
pubmed: 29162909
Int J Cardiol. 2018 Dec 1;272:244-249
pubmed: 30139700
BMC Nephrol. 2019 Aug 8;20(1):311
pubmed: 31395027
Intensive Care Med. 2010 Feb;36(2):304-11
pubmed: 19847398
Intensive Care Med. 2017 Aug;43(8):1105-1122
pubmed: 28676896
J Bras Nefrol. 2015 Jan-Mar;37(1):38-46
pubmed: 25923749
Lancet. 2015 Oct 10;386(10002):1465-71
pubmed: 26466051
Am J Med. 2009 Sep;122(9):857-65
pubmed: 19699382
Sci Rep. 2015 Sep 10;5:13925
pubmed: 26355041
Am J Kidney Dis. 2018 Jul;72(1):136-148
pubmed: 29478864
Clin Interv Aging. 2014 Nov 19;9:1987-92
pubmed: 25429210
Am J Respir Crit Care Med. 2014 May 1;189(9):1016-7
pubmed: 24787062
Arch Intern Med. 2010 Feb 8;170(3):294-302
pubmed: 20142578
Nephrol Dial Transplant. 2008 May;23(5):1562-8
pubmed: 18065827
Crit Care. 2016 Jul 04;20(1):188
pubmed: 27373891
Crit Care. 2008;12(6):R162
pubmed: 19094227
Nat Rev Nephrol. 2018 Oct;14(10):607-625
pubmed: 30135570
Med Sci Monit. 2012 Dec;18(12):CR729-34
pubmed: 23197235
Intensive Care Med. 2018 Jun;44(6):925-928
pubmed: 29675566
J Hosp Med. 2014 May;9(5):297-302
pubmed: 24523043
Am J Kidney Dis. 2018 Dec;72(6):846-856
pubmed: 29866457
Nat Rev Nephrol. 2014 Apr;10(4):193-207
pubmed: 24445744
Adv Chronic Kidney Dis. 2016 Jan;23(1):19-28
pubmed: 26709059
Am J Kidney Dis. 2007 Dec;50(6):952-7
pubmed: 18037096
Ann Intern Med. 2009 May 5;150(9):604-12
pubmed: 19414839
Nephrol Dial Transplant. 2010 Aug;25(8):2510-5
pubmed: 20167570
Crit Care Med. 2018 May;46(5):e380-e388
pubmed: 29373362
PLoS One. 2016 Jun 03;11(6):e0156444
pubmed: 27257823
Can J Anaesth. 2010 Jul;57(7):650-8
pubmed: 20405264
J Am Soc Nephrol. 2011 Jan;22(1):28-38
pubmed: 21209252