Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline.
allocentric
basal forebrain
entorhinal cortex
spatial navigation
subjective cognitive decline
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
08
2020
accepted:
27
01
2021
entrez:
4
3
2021
pubmed:
5
3
2021
medline:
5
3
2021
Statut:
epublish
Résumé
Individuals with subjective cognitive decline (SCD) are at higher risk of incipient Alzheimer's disease (AD). Spatial navigation (SN) impairments in AD dementia and mild cognitive impairment patients have been well-documented; however, studies investigating SN deficits in SCD subjects are still lacking. This study aimed to explore whether basal forebrain (BF) and entorhinal cortex (EC) atrophy contribute to spatial disorientation in the SCD stage. In total, 31 SCD subjects and 24 normal controls were enrolled and administered cognitive scales, a 2-dimensional computerized SN test, and structural magnetic resonance imaging (MRI) scanning. We computed the differences in navigation distance errors and volumes of BF subfields, EC, and hippocampus between the SCD and control groups. The correlations between MRI volumetry and navigation distance errors were also calculated. Compared with the controls, the SCD subjects performed worse in both egocentric and allocentric navigation. The SCD group showed volume reductions in the whole BF (
Identifiants
pubmed: 33658916
doi: 10.3389/fnagi.2021.596025
pmc: PMC7917187
doi:
Types de publication
Journal Article
Langues
eng
Pagination
596025Informations de copyright
Copyright © 2021 Chen, Wu, Li, Sun, Chen, Lu, Zhang, Liu, Qing, Nedelska, Hort, Zhang and Zhang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Neurodegener Dis. 2011;8(4):169-77
pubmed: 21124005
Biol Psychiatry. 2012 May 1;71(9):805-13
pubmed: 21816388
Neurology. 1984 Jun;34(6):741-5
pubmed: 6539435
Cortex. 2019 Oct;119:46-60
pubmed: 31071556
Alzheimers Dement (Amst). 2015 Dec 1;1(4):429-439
pubmed: 26878034
Science. 2000 Dec 22;290(5500):2315-9
pubmed: 11125148
Aging (Albany NY). 2018 Nov 4;10(11):3050-3051
pubmed: 30393235
Neurobiol Aging. 2015 Jun;36(6):2024-33
pubmed: 25862420
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2590-4
pubmed: 22308496
Neurobiol Aging. 2013 Apr;34(4):1210-20
pubmed: 23158764
Int J Geriatr Psychiatry. 2000 Jun;15(6):548-61
pubmed: 10861923
Cereb Cortex. 2012 Oct;22(10):2441-53
pubmed: 22095213
Neurodegener Dis. 2010;7(1-3):148-52
pubmed: 20197695
Neuropsychologia. 2014 Jan;53:54-63
pubmed: 24269297
J Gerontol. 1992 May;47(3):P154-8
pubmed: 1573197
Alzheimers Dement. 2014 Nov;10(6):844-52
pubmed: 24798886
Arch Clin Neuropsychol. 2006 Jan;21(1):23-8
pubmed: 16139470
Nat Rev Neurosci. 2009 Nov;10(11):792-802
pubmed: 19812579
Neurology. 2000 Jun 27;54(12):2261-8
pubmed: 10881250
PLoS One. 2013;8(2):e57333
pubmed: 23437370
J Comp Neurol. 1983 Feb 20;214(2):170-97
pubmed: 6841683
Dement Geriatr Cogn Disord. 2016;42(3-4):227-235
pubmed: 27701163
Front Aging Neurosci. 2012 Nov 01;4:29
pubmed: 23125833
Lancet Neurol. 2020 Mar;19(3):203-204
pubmed: 31958405
Behav Neurol. 2017;2017:6364314
pubmed: 29085184
Nature. 2010 Feb 4;463(7281):657-61
pubmed: 20090680
Neurosci Res. 2018 Apr;129:2-7
pubmed: 28476463
Neuropsychology. 2014 Sep;28(5):676-684
pubmed: 24749727
Neurobiol Aging. 2020 Jun;90:110-118
pubmed: 32171591
Ageing Res Rev. 2013 Jan;12(1):201-13
pubmed: 22771718
Neurodegener Dis. 2014;13(2-3):192-6
pubmed: 24192578
Cereb Cortex. 2010 Jul;20(7):1685-95
pubmed: 19889714
Alzheimers Dement. 2014 Oct;10(5 Suppl):S344-53
pubmed: 24418052
Neuroimage Clin. 2014 Nov 27;7:105-13
pubmed: 25610772
Science. 2015 Oct 23;350(6259):430-3
pubmed: 26494756
Nature. 2005 Aug 11;436(7052):801-6
pubmed: 15965463
CMAJ. 2006 Apr 11;174(8):1099-105
pubmed: 16554498
Neurology. 2006 Sep 12;67(5):834-42
pubmed: 16966547
Neurosci Biobehav Rev. 2019 Aug;103:33-49
pubmed: 31129234
Brain. 2019 Jun 1;142(6):1751-1766
pubmed: 31121601
PLoS One. 2013;8(1):e53472
pubmed: 23320088
J Neurosci. 2013 Apr 3;33(14):6012-7
pubmed: 23554482
Neuropsychologia. 2004;42(9):1212-22
pubmed: 15178173
J Neurosci. 2001 Oct 15;21(20):8164-73
pubmed: 11588189
Neuron. 2017 Aug 30;95(5):1019-1035
pubmed: 28858613
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4042-7
pubmed: 17360474
Nat Rev Neurol. 2018 Aug;14(8):496-506
pubmed: 29980763
Nat Protoc. 2006;1(2):892-9
pubmed: 17406322
Am J Geriatr Psychiatry. 2009 May;17(5):368-75
pubmed: 19390294
Front Syst Neurosci. 2010 May 14;4:13
pubmed: 20577591
PLoS One. 2012;7(12):e51157
pubmed: 23236445
Curr Opin Neurobiol. 2020 Feb;60:12-20
pubmed: 31794917
Int Psychogeriatr. 2017 May;29(5):785-792
pubmed: 28067183
Neurobiol Aging. 2006 Dec;27(12):1751-6
pubmed: 16309795
Front Aging Neurosci. 2015 Sep 28;7:185
pubmed: 26441643
Nat Commun. 2016 Nov 04;7:13249
pubmed: 27811848
Neurosci Biobehav Rev. 2017 Sep;80:605-621
pubmed: 28760627
Neuroimage. 2007 Oct 15;38(1):95-113
pubmed: 17761438
Brain. 2015 Oct;138(Pt 10):2814-33
pubmed: 26283673
Eur J Neurosci. 2018 Sep;48(5):2199-2230
pubmed: 30055067
J Am Geriatr Soc. 1992 Sep;40(9):922-35
pubmed: 1512391
Neurobiol Aging. 1990 Jan-Feb;11(1):3-13
pubmed: 2183081
BMJ Open. 2019 Jul 26;9(7):e028188
pubmed: 31350244
Lancet. 1976 Dec 25;2(8000):1403
pubmed: 63862
Acta Neuropathol. 2015 Apr;129(4):527-40
pubmed: 25633602
Front Neuroinform. 2019 Mar 22;13:13
pubmed: 30983985
J Neurosci. 2009 Apr 1;29(13):4120-30
pubmed: 19339607
Neurobiol Aging. 2018 Apr;64:107-115
pubmed: 29358117
Behav Brain Res. 2005 Apr 30;159(2):175-86
pubmed: 15817181
J Alzheimers Dis. 2014;40(3):687-700
pubmed: 24503619
Neuroimage. 2013 Jan 15;65:336-48
pubmed: 23041529
Hum Brain Mapp. 2011 Sep;32(9):1349-62
pubmed: 20672311
Cereb Cortex. 2016 Aug;26(8):3508-26
pubmed: 27230218
J Alzheimers Dis. 2015;45(1):139-46
pubmed: 25471190
Lancet Neurol. 2020 Mar;19(3):271-278
pubmed: 31958406
Alzheimers Dement. 2011 May;7(3):280-92
pubmed: 21514248
Alzheimers Dement. 2012 Oct;8(5 Suppl):S112-21
pubmed: 23021621
Neurology. 2000 Jun 27;54(12):2269-76
pubmed: 10881251
Neuroimage Clin. 2019;21:101612
pubmed: 30555006