A Novel Inflammatory Dendritic Cell That Is Abundant and Contiguous to T Cells in the Kidneys of Patients With Lupus Nephritis.
SLE
T cells
adaptive immune response
autoimmunity
inflammatory dendritic cells
kidney
lupus nephritis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
24
10
2020
accepted:
25
01
2021
entrez:
4
3
2021
pubmed:
5
3
2021
medline:
29
6
2021
Statut:
epublish
Résumé
The mechanisms that promote local inflammatory injury during lupus nephritis (LN) flare are largely unknown. Understanding the key immune cells that drive intrarenal inflammation will advance our knowledge of disease pathogenesis and inform the development of new therapeutics for LN management. In this study, we analyzed kidney biopsies from patients with proliferative LN and identified a novel inflammatory dendritic cell (infDC) population that is highly expressed in the LN kidney, but minimally present in healthy human kidneys. During an agnostic evaluation of immune transcript expression in the kidneys of patients with proliferative LN, the most abundantly overexpressed transcript from isolated glomeruli was
Identifiants
pubmed: 33659005
doi: 10.3389/fimmu.2021.621039
pmc: PMC7919935
doi:
Substances chimiques
Biomarkers
0
FCER1G, human
0
Receptors, Fc
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
621039Informations de copyright
Copyright © 2021 Parikh, Malvar, Shapiro, Turman, Song, Alberton, Lococo, Mejia-Vilet, Madhavan, Zhang, Yu, Satoskar, Birmingham, Jarjour, Rovin and Ganesan.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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