Use of Optogenetic Amyloid-β to Monitor Protein Aggregation in
Alzheimer’s Disease
Amyloid-β
Caenorhabditis elegans
Drosophila melanogaster
Light-sheet
Optogenetics
Zebrafish
Journal
Bio-protocol
ISSN: 2331-8325
Titre abrégé: Bio Protoc
Pays: United States
ID NLM: 101635102
Informations de publication
Date de publication:
05 Dec 2020
05 Dec 2020
Historique:
received:
22
06
2020
revised:
20
10
2020
accepted:
22
11
2020
entrez:
4
3
2021
pubmed:
5
3
2021
medline:
5
3
2021
Statut:
epublish
Résumé
Alzheimer's Disease (AD) has long been associated with accumulation of extracellular amyloid plaques (Aβ) originating from the Amyloid Precursor Protein. Plaques have, however, been discovered in healthy individuals and not all AD brains show plaques, suggesting that extracellular Aβ aggregates may play a smaller role than anticipated. One limitation to studying Aβ peptide
Identifiants
pubmed: 33659494
doi: 10.21769/BioProtoc.3856
pii: e3856
pmc: PMC7842303
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e3856Informations de copyright
Copyright © The Authors; exclusive licensee Bio-protocol LLC.
Déclaration de conflit d'intérêts
Competing interestsWe have no conflicts of interest to declare.
Références
J Dev Biol. 2017 Dec 22;6(1):
pubmed: 29615550
Genetics. 2004 Apr;166(4):1775-82
pubmed: 15126397
Dev Biol. 2011 Apr 15;352(2):191-201
pubmed: 21223961
Nat Methods. 2013 Mar;10(3):249-52
pubmed: 23377377
Nat Genet. 2008 Apr;40(4):476-83
pubmed: 18311141
J Mol Biol. 2020 May 1;432(10):3159-3176
pubmed: 32201167
Nature. 2000 Nov 9;408(6809):207-11
pubmed: 11089975
Genetics. 2016 Aug;203(4):1613-28
pubmed: 27334272
Annu Rev Neurosci. 2011;34:389-412
pubmed: 21692661
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21171-6
pubmed: 24327734
BMJ. 2016 Nov 29;355:i6389
pubmed: 27899350
Pharmacol Rep. 2015 Apr;67(2):195-203
pubmed: 25712639
Subcell Biochem. 2012;65:329-52
pubmed: 23225010
Neurobiol Learn Mem. 2011 Nov;96(4):529-43
pubmed: 21914486
Nat Rev Neurosci. 2007 Jul;8(7):499-509
pubmed: 17551515
Alzheimers Dement (N Y). 2018 May 03;4:195-214
pubmed: 29955663
Mol Brain. 2011 Jan 07;4:3
pubmed: 21214928
J Vis Exp. 2011 Mar 24;(49):
pubmed: 21490567
Science. 1992 Apr 10;256(5054):184-5
pubmed: 1566067
Genome Biol. 2007;8 Suppl 1:S7
pubmed: 18047699
WormBook. 2006 Feb 11;:1-11
pubmed: 18050451
Sci Rep. 2017 Nov 30;7(1):16636
pubmed: 29192250
Nat Methods. 2010 Dec;7(12):973-5
pubmed: 21037589
Sci Rep. 2016 Sep 22;6:33781
pubmed: 27653553
Elife. 2020 Mar 31;9:
pubmed: 32228858
Biogerontology. 2011 Jun;12(3):195-209
pubmed: 21153705
Photochem Photobiol Sci. 2010 Oct 28;9(10):1286-300
pubmed: 20835487
Development. 1993 Jun;118(2):401-15
pubmed: 8223268
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3312-7
pubmed: 17360644