Natural antioxidants for neuroinflammatory disorders and possible involvement of Nrf2 pathway: A review.

Natural compounds Neuroinflammatory disorders Neuroprotective effects Nrf2 pathway

Journal

Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560

Informations de publication

Date de publication:
Feb 2021
Historique:
received: 20 03 2020
revised: 21 05 2020
accepted: 04 02 2021
entrez: 4 3 2021
pubmed: 5 3 2021
medline: 5 3 2021
Statut: epublish

Résumé

The transcription factor Nrf2 (nuclear factor-erythroid 2 p45-related factor 2) play a crucial role in cellular redox and metabolic system. Activation of Nrf2 may be an effective therapeutic approach for neuroinflammatory disorders, through activation of antioxidant defences system, lower the inflammation, line up the mitochondrial function, and balancing of protein homeostasis. Various recent studies revealed that many of active substance obtained from plants have been found to activate the Nrf2 and to exert neuroprotective effects in various experimental models, raising the possibility that activation of Nrf2 may be an effective therapeutic approaches for neuroinflammatory disorders. The objective of this review was to evaluate the neuroprotective property of natural substance against neuroinflammatory disorders by reviewing the studies done till today. The outcomes of various

Identifiants

DOI: 10.1016/j.heliyon.2021.e06216 PMID: 33659743 PMC: PMC7890213
pubmed: 33659743
doi: 10.1016/j.heliyon.2021.e06216
pii: S2405-8440(21)00321-2
pmc: PMC7890213
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

e06216

Informations de copyright

© 2021 Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Sanjiv Singh (S)

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Export Promotion Industrial Park (EPIP), Zandaha Road, Hajipur, Bihar, India.

Devarapati Nagalakshmi (D)

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Export Promotion Industrial Park (EPIP), Zandaha Road, Hajipur, Bihar, India.

K K Sharma (KK)

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Export Promotion Industrial Park (EPIP), Zandaha Road, Hajipur, Bihar, India.

V Ravichandiran (V)

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Export Promotion Industrial Park (EPIP), Zandaha Road, Hajipur, Bihar, India.

Classifications MeSH