An updated toolkit for exploring bacterial cell wall structure and dynamics.

AFM Cryo-EM FDAA peptidoglycan ultra performance liquid chromatography

Journal

Faculty reviews
ISSN: 2732-432X
Titre abrégé: Fac Rev
Pays: England
ID NLM: 101769226

Informations de publication

Date de publication:
2021
Historique:
entrez: 4 3 2021
pubmed: 5 3 2021
medline: 5 3 2021
Statut: epublish

Résumé

The bacterial cell wall is made primarily from peptidoglycan, a complex biomolecule which forms a bag-like exoskeleton that envelops the cell. As it is unique to bacteria and typically essential for their growth and survival, it represents one of the most successful targets for antibiotics. Although peptidoglycan has been studied intensively for over 50 years, the past decade has seen major steps in our understanding of this molecule because of the advent of new analytical and imaging methods. Here, we outline the most recent developments in tools that have helped to elucidate peptidoglycan structure and dynamics.

Identifiants

pubmed: 33659932
doi: 10.12703/r/10-14
pmc: PMC7894271
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

14

Informations de copyright

Copyright: © 2021 Cava F et al.

Déclaration de conflit d'intérêts

The authors declare that they have no competing interests.No competing interests were disclosed.No competing interests were disclosed.

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Auteurs

Michael C Gilmore (MC)

Laboratory for Molecular Infection Medicine Sweden (MIMS), Department of Molecular Biology, Umeå University, Umeå, Sweden.

Barbara Ritzl-Rinkenberger (B)

Laboratory for Molecular Infection Medicine Sweden (MIMS), Department of Molecular Biology, Umeå University, Umeå, Sweden.

Felipe Cava (F)

Laboratory for Molecular Infection Medicine Sweden (MIMS), Department of Molecular Biology, Umeå University, Umeå, Sweden.

Classifications MeSH