Human milk proteome: what's new?
Journal
Current opinion in clinical nutrition and metabolic care
ISSN: 1473-6519
Titre abrégé: Curr Opin Clin Nutr Metab Care
Pays: England
ID NLM: 9804399
Informations de publication
Date de publication:
01 05 2021
01 05 2021
Historique:
pubmed:
5
3
2021
medline:
26
10
2021
entrez:
4
3
2021
Statut:
ppublish
Résumé
The proteome is one of the most complicated and multifunctional components in human milk. Recently, numerous novel characteristics of the human milk proteome have been discovered, which are described and critically examined in this review. Recent human milk proteomics studies have focused on how external factors like geography and environment, or maternal and infant's factors affect the milk proteins, endogenous peptides, their posttransitional modifications (PTMs) and infant utilization. Most of these studies have shown that major protein and endogenous peptide profiles are similar for healthy women and infants. The human milk proteome has been expanded by providing novel insights into PTMs like glycosylation and phosphorylation, and how the proteins and peptides are digested and utilized by the infant. All human milk proteomics studies are subject to conditions in which the samples were collected, handled and stored. Significant technological advancements in mass spectrometry have considerably enabled a deeper and more comprehensive identification and characterization of the expanded human milk proteome. However, data concerning human milk from mothers with infections or illnesses and mothers nursing more vulnerable infants are still limited and the roles of the components of the human milk proteome have not yet been sufficiently elucidated.
Identifiants
pubmed: 33660633
doi: 10.1097/MCO.0000000000000742
pii: 00075197-202105000-00010
doi:
Substances chimiques
Milk Proteins
0
Proteome
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
252-258Informations de copyright
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.
Références
Bode L, Raman AS, Murch SH, et al. Understanding the mother–breastmilk–infant ‘triad’. Science 2020; 367:1070–1072.
Zhu J, Dingess KA. The functional power of the human milk proteome. Nutrients 2019; 11:1834.
Dixit SJ, Kk AK, Singh K. Study of human allergic milk whey protein from different mammalian species using computational method. Bioinformation 2012; 8:1035–1041.
Donovan SM. Human milk proteins: composition and physiological significance. Nestle Nutr Inst Workshop Ser 2019; 90:93–101.
Dingess KA, van den Toorn HWP, Mank M, et al. Toward an efficient workflow for the analysis of the human milk peptidome. Anal Bioanal Chem 2019; 411:1351–1363.
Liu B, Gu F, Ye W, et al. Colostral and mature breast milk protein compositional determinants in Qingdao, Wuhan and Hohhot: maternal food culture, vaginal delivery and neonatal gender. Asia Pac J Clin Nutr 2019; 28:800–811.
Liao Y, Weber D, Xu W, et al. Absolute quantification of human milk caseins and the whey/casein ratio during the first year of lactation. J Proteome Res 2017; 16:4113–4121.
Zhu J, Garrigues L, Van Den Toorn H, et al. Discovery and quantification of nonhuman proteins in human milk. J Proteome Res 2019; 18:225–238.
Picariello G, De Cicco M, Nocerino R, et al. Excretion of dietary cow's milk derived peptides into breast milk. Front Nutr 2019; 6:25.
Elwakiel M, Boeren S, Hageman JA, et al. Variability of serum proteins in Chinese and Dutch human milk during lactation. Nutrients 2019; 11:499.
Zhang L, Ma Y, Yang Z, et al. Geography and ethnicity related variation in the Chinese human milk serum proteome. Food Funct 2019; 10:7818–7827.
Goonatilleke E, Huang J, Xu G, et al. Human milk proteins and their glycosylation exhibit quantitative dynamic variations during lactation. J Nutr 2019; 149:1317–1325.
Elwakiel M, Bakx EJ, Szeto IM, et al. Serum protein N -glycans in colostrum and mature milk of chinese mothers. J Agric Food Chem 2020; 68:6873–6883.
Caval T, Heck AJR, Reiding KR. Meta-heterogeneity: evaluating and describing the diversity in glycosylation between sites on the same glycoprotein. Mol Cell Proteomics 2020; 20:100010.
Zhu J, Lin YH, Dingess KA, et al. Quantitative longitudinal inventory of the N -glycoproteome of human milk from a single donor reveals the highly variable repertoire and dynamic site-specific changes. J Proteome Res 2020; 19:1941–1952.
Picariello G, Ferranti P, Mamone G, et al. Identification of N -linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. Proteomics 2008; 8:3833–3847.
Cao X, Yang M, Yang N, et al. Characterization and comparison of whey N -glycoproteomes from human and bovine colostrum and mature milk. Food Chem 2019; 276:266–273.
Cao X, Zheng Y, Wu S, et al. Characterization and comparison of milk fat globule membrane N -glycoproteomes from human and bovine colostrum and mature milk. Food Funct 2019; 10:5046–5058.
Yang M, Deng W, Cao X, et al. Quantitative phosphoproteomics of milk fat globule membrane in human colostrum and mature milk: new insights into changes in protein phosphorylation during lactation. J Agric Food Chem 2020; 68:4546–4556.
Dallas DC, Guerrero A, Khaldi N, et al. Extensive in vivo human milk peptidomics reveals specific proteolysis yielding protective antimicrobial peptides. J Proteome Res 2013; 12:2295–2304.
Wada Y, Lonnerdal B. Bioactive peptides derived from human milk proteins: an update. Curr Opin Clin Nutr Metab Care 2020; 23:217–222.
Beverly RL, Huston RK, Markell AM, et al. Differences in human milk peptide release along the gastrointestinal tract between preterm and term infants. Clin Nutr 2020; [Online ahead of print].
Beverly RL, Underwood MA, Dallas DC. Peptidomics analysis of milk protein-derived peptides released over time in the preterm infant stomach. J Proteome Res 2019; 18:912–922.
Nielsen SD, Beverly RL, Underwood MA, Dallas DC. Differences and similarities in the peptide profile of preterm and term mother's milk, and preterm and term infant gastric samples. Nutrients 2020; 12:2825.
Deglaire A, Oliveira S, Jardin J, et al. Impact of human milk pasteurization on the kinetics of peptide release during in vitro dynamic digestion at the preterm newborn stage. Food Chem 2019; 281:294–303.
Zhou Y, Zhang L, Yu Z, et al. Peptidomic analysis reveals multiple protection of human breast milk on infants during different stages. J Cell Physiol 2019; 234:15510–15526.
Gan J, Robinson RC, Wang J, et al. Peptidomic profiling of human milk with LC–MS/MS reveals pH-specific proteolysis of milk proteins. Food Chem 2019; 274:766–774.
Gan J, Zheng J, Krishnakumar N, et al. Selective proteolysis of α-lactalbumin by endogenous enzymes of human milk at acidic pH. Mol Nutr Food Res 2019; 63:e1900259.
Casavale KO, Ahuja JKC, Wu X, et al. NIH workshop on human milk composition: summary and visions. Am J Clin Nutr 2019; 110:769–779.
Geraghty SR, Davidson BS, Warner BB, et al. The development of a research human milk bank. J Hum Lact 2005; 21:59–66.
Howland V, Klaedtke M, Ruhnau J, et al. Impact of storage conditions on the breast milk peptidome. Nutrients 2020; 12:2733.
Zhang L, Wu Y, Ma Y, et al. Macronutrients, total aerobic bacteria counts and serum proteome of human milk during refrigerated storage. Food Biosci 2020; 35:100562.
Hahn WH, Bae SP, Lee H, et al. The impact of freeze–drying on the glycoproteomic profiles of human milk. Anal Sci Technol 2020; 33:177–185.
Hahn WH, Bae SP, Song S, et al. The freeze–drying does not influence the proteomic profiles of human milk. J Matern Fetal Neonatal Med 2020; 33:2069–2074.
Nebbia S, Giribaldi M, Cavallarin L, et al. Differential impact of holder and high temperature short time pasteurization on the dynamic in vitro digestion of human milk in a preterm newborn model. Food Chem 2020; 328:127126.
Ma Y, Zhang L, Wu Y, Zhou P. Changes in milk fat globule membrane proteome after pasteurization in human, bovine and caprine species. Food Chem 2019; 279:209–215.
Aslebagh R, Channaveerappa D, Pentecost BT, et al. Combinatorial electrophoresis and mass spectrometry-based proteomics in breast milk for breast cancer biomarker discovery. Adv Exp Med Biol 2019; 1140:451–467.
Kim BJ, Dallas DC. Systematic examination of protein extraction, proteolytic glycopeptide enrichment and MS/MS fragmentation techniques for site-specific profiling of human milk N -glycoproteins. Talanta 2020; 224:121811.