Dynamic expression of NR2F1 and SOX2 in developing and adult human cortex: comparison with cortical malformations.
BBSOAS
Cortical dysplasia
Human cortical development
NR2F1/COUP-TF1
SOX2
Transcription factors
Journal
Brain structure & function
ISSN: 1863-2661
Titre abrégé: Brain Struct Funct
Pays: Germany
ID NLM: 101282001
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
03
09
2020
accepted:
22
02
2021
pubmed:
5
3
2021
medline:
1
12
2021
entrez:
4
3
2021
Statut:
ppublish
Résumé
The neocortex, the most recently evolved brain region in mammals, is characterized by its unique areal and laminar organization. Distinct cortical layers and areas can be identified by the presence of graded expression of transcription factors and molecular determinants defining neuronal identity. However, little is known about the expression of key master genes orchestrating human cortical development. In this study, we explored the expression dynamics of NR2F1 and SOX2, key cortical genes whose mutations in human patients cause severe neurodevelopmental syndromes. We focused on physiological conditions, spanning from mid-late gestational ages to adulthood in unaffected specimens, but also investigated gene expression in a pathological context, a developmental cortical malformation termed focal cortical dysplasia (FCD). We found that NR2F1 follows an antero-dorsal
Identifiants
pubmed: 33661352
doi: 10.1007/s00429-021-02242-7
pii: 10.1007/s00429-021-02242-7
doi:
Substances chimiques
COUP Transcription Factor I
0
NR2F1 protein, human
0
SOX2 protein, human
0
SOXB1 Transcription Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1303-1322Subventions
Organisme : European Research Area Networks (ERA-NET) Neuron II
ID : RE7-n.363/2016
Organisme : European Research Area Networks (ERA-NET) Neuron II
ID : ANR-15-NEUR-0002-04
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