SARS-CoV-2: Insights into its structural intricacies and functional aspects for drug and vaccine development.
COVID-19
Coronaviruses
SARS-CoV
SARS-CoV-2
Spike protein
Vaccine
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
15 May 2021
15 May 2021
Historique:
received:
09
10
2020
revised:
04
01
2021
accepted:
27
02
2021
pubmed:
5
3
2021
medline:
11
5
2021
entrez:
4
3
2021
Statut:
ppublish
Résumé
Globally, SARS-CoV-2 has emerged as threat to life and economy. Researchers are trying to find a cure against this pathogen but without much success. Several attempts have been made to understand the atomic level details of SARS-CoV-2 in the past few months. However, one review with all structural details for drug and vaccine development has been missing. Hence, this review aims to summarize key functional roles played by various domains of SARS-CoV-2 genome during its entry into the host, replication, repression of host immune response and overall viral life cycle. Additionally, various proteins of SARS-CoV-2 for finding a potent inhibitor have also been highlighted. To mitigate this deadly virus, an understanding of atomic level information, pathogenicity mechanisms and functions of different proteins in causing the infection is imperative. Thus, these structural details would finally pave the way for development of a potential drug/vaccine against the disease caused by SARS-CoV-2.
Identifiants
pubmed: 33662418
pii: S0141-8130(21)00510-9
doi: 10.1016/j.ijbiomac.2021.02.212
pmc: PMC7919520
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
45-60Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest No conflict of interest declared.
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