FOXO1 expression in chondrocytes modulates cartilage production and removal in fracture healing.

Animals Bony Callus Cartilage Chondrocytes Forkhead Box Protein O1 / genetics Fracture Healing Mice Osteoclasts
Cartilage Chondrocyte Fracture Healing Inflammation Osteoclast

Journal

Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048

Informations de publication

Date de publication:
07 2021
Historique:
received: 26 02 2020
revised: 15 02 2021
accepted: 24 02 2021
pubmed: 5 3 2021
medline: 10 7 2021
entrez: 4 3 2021
Statut: ppublish

Résumé

Fracture healing is a multistage process characterized by inflammation, cartilage formation, bone deposition, and remodeling. Chondrocytes are important in producing cartilage that forms the initial anlagen for the hard callus needed to stabilize the fracture site. We examined the role of FOXO1 by selective ablation of FOXO1 in chondrocytes mediated by Col2α1 driven Cre recombinase. Experimental mice with lineage-specific FOXO1 deletion (Col2α1Cre

Identifiants

DOI: 10.1016/j.bone.2021.115905 PMID: 33662610 PMC: PMC8106874
pubmed: 33662610
pii: S8756-3282(21)00067-3
doi: 10.1016/j.bone.2021.115905
pmc: PMC8106874
mid: NIHMS1685192
pii:
doi:

Substances chimiques

Forkhead Box Protein O1 0
Foxo1 protein, mouse 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

115905

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR060055
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE017732
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE027074
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR069619
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE019108
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

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Auteurs

Zhenjiang Ding (Z)

Department of Pediatric Dentistry, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, China; Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Min Qiu (M)

Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Orthopaedic Surgery, Shengjing Hospital, China Medical University, Shenyang, China.

Mohammed A Alharbi (MA)

Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Endodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.

Tiffany Huang (T)

Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Xiyan Pei (X)

Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA; First Clinical Division, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, China.

Tatyana N Milovanova (TN)

Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Hongli Jiao (H)

Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Chanyi Lu (C)

Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Min Liu (M)

Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Ling Qin (L)

McKay Orthopaedic Research Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Dana T Graves (DT)

Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: dtgraves@upenn.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › FOXO1 expression in chondrocytes modulates...
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › Cal osseux › FOXO1 expression in chondrocytes modulates...
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › FOXO1 expression in chondrocytes modulates...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Chondrocytes › FOXO1 expression in chondrocytes modulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Protéine O1 à motif en tête de fourche › FOXO1 expression in chondrocytes modulates...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Cicatrisation de plaie › Consolidation de fracture › FOXO1 expression in chondrocytes modulates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › FOXO1 expression in chondrocytes modulates...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Ostéoclastes › FOXO1 expression in chondrocytes modulates...