Pulmonary and cardiac variables associated with persistent dyspnea after pulmonary embolism.

Cross-Sectional Studies Dyspnea / etiology Humans Lung Pulmonary Embolism / complications Venous Thromboembolism
Dyspnea Echocardiography Pulmonary embolism Radionuclide imaging Respiratory function tests

Journal

Thrombosis research
ISSN: 1879-2472
Titre abrégé: Thromb Res
Pays: United States
ID NLM: 0326377

Informations de publication

Date de publication:
05 2021
Historique:
received: 10 11 2020
revised: 12 01 2021
accepted: 09 02 2021
pubmed: 5 3 2021
medline: 22 6 2021
entrez: 4 3 2021
Statut: ppublish

Résumé

Persistent dyspnea is common in follow-up after pulmonary embolism (PE), but the underlying mechanisms are poorly understood. This cross-sectional study included subjects aged 18-75 years with confirmed PE by computed tomography pulmonary angiography (CTPA) 6-72 months earlier. A total of 180 participants underwent clinical examination, incremental shuttle walk test, laboratory tests, transthoracic echocardiography, pulmonary function tests and ventilation/perfusion scintigraphy. In further analysis, we divided participants into two groups; "dyspnea" or "no dyspnea", based on interview and questionnaires at inclusion. The association of cardiac and pulmonary variables with persistent dyspnea was assessed using multiple logistic regression analysis. In total, 44% (95% CI: 39%-51%) of the participants reported persistent dyspnea after PE. Age (adjusted odds ratio (aOR) 0.93 per year, 95% CI: 0.90-0.97, P = 0.001), body mass index (BMI) (aOR 1.14 per kg/m Persistent dyspnea was prevalent after PE. Age, BMI and recurrent VTE were independently associated with dyspnea. Apart from reduced DLCO, no other cardiac or pulmonary variables were associated with persistent dyspnea.

Identifiants

DOI: 10.1016/j.thromres.2021.02.014 PMID: 33662800
pubmed: 33662800
pii: S0049-3848(21)00062-1
doi: 10.1016/j.thromres.2021.02.014
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

90-99

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Øyvind Jervan (Ø)

Department of Cardiology, Østfold Hospital, Kalnes, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: Oyvind.Jervan@so-hf.no.

Jostein Gleditsch (J)

Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Radiology, Østfold Hospital, Kalnes, Norway.

Mazdak Tavoly (M)

Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.

Frederikus A Klok (FA)

Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.

Diyar Rashid (D)

Department of Radiology, Østfold Hospital, Kalnes, Norway.

René Holst (R)

Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Kjetil Steine (K)

Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Cardiology, Akershus University Hospital, Lørenskog, Norway.

Knut Stavem (K)

Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Pulmonary Medicine, Akershus University Hospital, Lørenskog, Norway; Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway.

Waleed Ghanima (W)

Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Medicine, Østfold Hospital, Kalnes, Norway; Dept of hematology, Oslo University hospital, Oslo, Norway.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Pulmonary and cardiac variables associated...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Dyspnée › Pulmonary and cardiac variables associated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pulmonary and cardiac variables associated...
questionsmedicales.fr › Appareil respiratoire › Poumon › Pulmonary and cardiac variables associated...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Embolie › Embolie pulmonaire › Pulmonary and cardiac variables associated...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thromboembolie › Thromboembolisme veineux › Pulmonary and cardiac variables associated...