Effectiveness and safety of Liuhedan for treating acute pancreatitis: A protocol for systematic review and meta analysis.
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
26 Feb 2021
26 Feb 2021
Historique:
received:
27
01
2021
accepted:
29
01
2021
entrez:
5
3
2021
pubmed:
6
3
2021
medline:
16
3
2021
Statut:
ppublish
Résumé
Liuhedan is a famous traditional Chinese medicine (TCM) formula used to treat acute pancreatitis (AP) in China. However, there is no systematic reviews for the evidence and the therapeutic effectiveness and safety of Liuhedan for treating AP. The aim of this study is to summarize previous evidence, assessing the efficacy and safety of Liuhedan in the treatment of AP. We will search the EMBASE, WANFANG DATA, Web of Knowledge, CNKI, PubMed, ClinicalTrials.gov and Cochrane Library from inception to June 30, 2021 to retrieve relevant studies using the search strategy: ("Liuhedan" OR "Liuhe Pill" OR "Liu-He-Dan") AND ("pancreatitis" OR "pancreatitides"). Two authors independently judged study eligibility and extracted data. Heterogeneity will be examined by computing the Q statistic and I2 statistic. This study assessed the efficiency and safety of Liuhedan for treating acute pancreatitis. This study will provide reliable evidence-based evidence for the clinical application of Liuhedan for treating AP. Ethical approval is unnecessary as this protocol is only for systematic review and does not involve privacy data. The findings of this study will be disseminated electronically through a peer-review publication or presented at a relevant conference.
Sections du résumé
BACKGROUND
BACKGROUND
Liuhedan is a famous traditional Chinese medicine (TCM) formula used to treat acute pancreatitis (AP) in China. However, there is no systematic reviews for the evidence and the therapeutic effectiveness and safety of Liuhedan for treating AP. The aim of this study is to summarize previous evidence, assessing the efficacy and safety of Liuhedan in the treatment of AP.
METHODS
METHODS
We will search the EMBASE, WANFANG DATA, Web of Knowledge, CNKI, PubMed, ClinicalTrials.gov and Cochrane Library from inception to June 30, 2021 to retrieve relevant studies using the search strategy: ("Liuhedan" OR "Liuhe Pill" OR "Liu-He-Dan") AND ("pancreatitis" OR "pancreatitides"). Two authors independently judged study eligibility and extracted data. Heterogeneity will be examined by computing the Q statistic and I2 statistic.
RESULTS
RESULTS
This study assessed the efficiency and safety of Liuhedan for treating acute pancreatitis.
CONCLUSIONS
CONCLUSIONS
This study will provide reliable evidence-based evidence for the clinical application of Liuhedan for treating AP.
ETHICS AND DISSEMINATION
BACKGROUND
Ethical approval is unnecessary as this protocol is only for systematic review and does not involve privacy data. The findings of this study will be disseminated electronically through a peer-review publication or presented at a relevant conference.
Identifiants
pubmed: 33663109
doi: 10.1097/MD.0000000000024863
pii: 00005792-202102260-00072
pmc: PMC7909230
doi:
Substances chimiques
Drugs, Chinese Herbal
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e24863Subventions
Organisme : the Science Foundation of Science and Technology Department of Sichuan
ID : No. 2018SZ0390
Informations de copyright
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to disclose.
Références
Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis-2012: revision of the Atlanta classification and definitions by international consensus. Gut 2013;62:102–11.
Waldron RT, Lugea A, Gulla A, et al. Proteomic identification of novel plasma biomarkers and pathobiologic pathways in alcoholic acute pancreatitis. Front Physiol 2018;9:1215.
Lee PJ, Papachristou GI. New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol 2019;1.
Peery AF, Dellon ES, Lund J, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology 2012;143:1179–87.e1173.
Wu J, Zhou G. The preliminary investigation of Liu-hedan in the treatment of furuncle and phyma. J Tradit Chin Med (Chin) 1957;7:372–4.
Xie D, Wu G. The clinical investigation of Liu-he-dan on the treatment of sores of yang syndromes. Sichuan J Tradit Chin Med (Chin) 1985;12:30–1.
Whiting PF, Rutjes AW, Westwood ME, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med 2011;155:529–36.
Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010;25:603–5.
Bradley EL 3rd. A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13. Arch Surg 1993;128:586–90.
Remes-Troche JM, Duarte-Rojo A, Morales G, et al. Hemoconcentration is a poor predictor of severity in acute pancreatitis. World J Gastroenterol 2005;11:7018–23.
Charalabopoulos A, Davakis S, Lambropoulou M, et al. Apigenin exerts anti-inflammatory effects in an experimental model of acute pancreatitis by down-regulating TNF-alpha. In Vivo 2019;33:1133–41.
Pintado MC, Trascasa M, Arenillas C, et al. New Atlanta classification of acute pancreatitis in intensive care unit: Complications and prognosis. Eur J Intern Med 2016;30:82–7.
Farkas N, Hanák L, Mikó A, et al. A multicenter, international cohort analysis of 1435 cases to support clinical trial design in acute pancreatitis. Front Physiol 2019;10:1092.
Kylänpää M-L, Repo H, Puolakkainen PA. Inflammation and immunosuppression in severe acute pancreatitis. World J Gastroenterol 2010;16:2867.
Munir F, Jamshed MB, Shahid N, et al. Advances in immunomodulatory therapy for severe acute pancreatitis. Immunol Lett 2020;217:72–6.
Gong H-l, Tang W-f, Ren Y-y, et al. Summary of integrative medicine for severe acute pancreatitis: 26-year clinical experiences and a report of 1,561 cases. Chin J Integr Med 2011;17:381–5.
Liu X, Jiang J, Huang Z, et al. Clinical study on the treatment of severe acute pancreatitis by integrated traditional Chinese medicine and Western medicine. Sichuan da xue xue bao Yi xue ban 2004;35:204–8.