Resistance of strongylid nematodes to anthelmintic drugs and driving factors at Czech goat farms.
Caprine gastrointestinal nematodes
Control
Dual resistance
Farmer experience
In vitro test
Stocking rate
Journal
BMC veterinary research
ISSN: 1746-6148
Titre abrégé: BMC Vet Res
Pays: England
ID NLM: 101249759
Informations de publication
Date de publication:
05 Mar 2021
05 Mar 2021
Historique:
received:
26
08
2020
accepted:
25
02
2021
entrez:
5
3
2021
pubmed:
6
3
2021
medline:
10
8
2021
Statut:
epublish
Résumé
Strongylid nematode infections may negatively affect both animal health and welfare, with deleterious consequences for livestock productivity. Many farmers in recent decades have relied on anthelmintics as the sole strategy of control, but the intensive use of these chemotherapeutics has led to the development of anthelmintic resistance (AR). Knowledge of both the efficacy of anthelmintics and factors promoting AR are essential to effectively control nematode infections, but no information on these topics for goats in the Czech Republic (CR) is available. This survey aimed to determine the occurrence of AR at Czech goat farms and to identify risk factors for the development of AR. A total of 24 herds of dairy goats across the CR were evaluated using in vitro tests for detecting AR, and a questionnaire survey was carried out to evaluate factors associated with AR. Resistance against benzimidazoles was confirmed at 18 (75%) farms, and the level of resistance was high in four (22%) of the affected herds based on the egg hatch test. Ivermectin-resistant nematodes were detected in 13 (54%) herds using the larval development test; Teladorsagia/Trichostrongylus and Haemonchus were the predominant types of resistant larvae. Eight (62%) of the affected herds were evaluated as highly resistant to ivermectin. Eleven (46%) of the herds were resistant to both benzimidazoles and ivermectin. This report is the first on dual AR in the CR. A univariate logistic regression analysis indicated that a high stocking rate and farmer inexperience were significantly associated with ivermectin and benzimidazole resistance, respectively. The results of our survey suggest that AR is widespread amongst herds of dairy goats in the CR, likely due to inappropriate practices of pasture and health management. AR may be an issue for expanding dairy-goat production in the CR in the near future unless both veterinary practitioners and farmers widely adopt strategies to prevent the development of AR.
Sections du résumé
BACKGROUND
BACKGROUND
Strongylid nematode infections may negatively affect both animal health and welfare, with deleterious consequences for livestock productivity. Many farmers in recent decades have relied on anthelmintics as the sole strategy of control, but the intensive use of these chemotherapeutics has led to the development of anthelmintic resistance (AR). Knowledge of both the efficacy of anthelmintics and factors promoting AR are essential to effectively control nematode infections, but no information on these topics for goats in the Czech Republic (CR) is available. This survey aimed to determine the occurrence of AR at Czech goat farms and to identify risk factors for the development of AR. A total of 24 herds of dairy goats across the CR were evaluated using in vitro tests for detecting AR, and a questionnaire survey was carried out to evaluate factors associated with AR.
RESULTS
RESULTS
Resistance against benzimidazoles was confirmed at 18 (75%) farms, and the level of resistance was high in four (22%) of the affected herds based on the egg hatch test. Ivermectin-resistant nematodes were detected in 13 (54%) herds using the larval development test; Teladorsagia/Trichostrongylus and Haemonchus were the predominant types of resistant larvae. Eight (62%) of the affected herds were evaluated as highly resistant to ivermectin. Eleven (46%) of the herds were resistant to both benzimidazoles and ivermectin. This report is the first on dual AR in the CR. A univariate logistic regression analysis indicated that a high stocking rate and farmer inexperience were significantly associated with ivermectin and benzimidazole resistance, respectively.
CONCLUSIONS
CONCLUSIONS
The results of our survey suggest that AR is widespread amongst herds of dairy goats in the CR, likely due to inappropriate practices of pasture and health management. AR may be an issue for expanding dairy-goat production in the CR in the near future unless both veterinary practitioners and farmers widely adopt strategies to prevent the development of AR.
Identifiants
pubmed: 33663490
doi: 10.1186/s12917-021-02819-8
pii: 10.1186/s12917-021-02819-8
pmc: PMC7934424
doi:
Substances chimiques
Anthelmintics
0
Benzimidazoles
0
Ivermectin
70288-86-7
benzimidazole
E24GX49LD8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106Subventions
Organisme : Ministerstvo Školství, Mládeže a Tělovýchovy
ID : LTC19018
Références
Onderstepoort J Vet Res. 2013 Mar 13;80(1):539
pubmed: 23718204
Parasitology. 2002 Oct;125(Pt 4):375-81
pubmed: 12403326
Parasitology. 2006 Sep;133(Pt 3):345-56
pubmed: 16762091
Vet Parasitol. 2006 Mar 31;136(3-4):167-85
pubmed: 16427201
BMC Vet Res. 2019 Jun 27;15(1):216
pubmed: 31248417
Parasitology. 2000;120 Suppl:S95-107
pubmed: 10874713
Vet Parasitol. 1992 Sep;44(1-2):35-44
pubmed: 1441190
BMC Vet Res. 2014 Oct 01;10:233
pubmed: 25270360
Parasitol Res. 2012 Jul;111(1):185-93
pubmed: 22290446
Vet Parasitol. 1995 Dec;60(3-4):331-7
pubmed: 8747916
Vet Rec. 2014 Sep 13;175(10):250-5
pubmed: 25217603
Vet Rec. 1992 May 16;130(20):442-6
pubmed: 1621342
Wien Klin Wochenschr. 2009 Oct;121 Suppl 3:46-9
pubmed: 19915817
Parasitol Res. 2012 Nov;111(5):2201-4
pubmed: 22581298
Trends Parasitol. 2010 Aug;26(8):376-81
pubmed: 20488752
Vet Res Commun. 2000 Nov;24(7):459-69
pubmed: 11085466
BMC Vet Res. 2014 May 19;10:114
pubmed: 24886141
Vet Parasitol. 2005 Mar 31;128(3-4):285-90
pubmed: 15740865
Vet Parasitol. 1996 Nov 1;66(1-2):53-66
pubmed: 8988556
Vet Parasitol. 2018 Apr 30;254:10-14
pubmed: 29656993
Asian-Australas J Anim Sci. 2019 Aug;32(8):1219-1232
pubmed: 31357263
Vet Res. 2002 Sep-Oct;33(5):465-80
pubmed: 12387484
Prev Vet Med. 2014 Nov 15;117(2):388-402
pubmed: 25059197
Int J Parasitol. 1995 Jun;25(6):691-8
pubmed: 7657454
Parasitology. 2018 Nov;145(13):1655-1664
pubmed: 29415781
Vet Parasitol. 2007 Mar 15;144(1-2):68-73
pubmed: 17088023
J Helminthol. 2001 Dec;75(4):325-30
pubmed: 11818048
Can J Comp Med. 1982 Apr;46(2):133-7
pubmed: 7093809
Vet Parasitol. 2012 May 4;186(1-2):70-8
pubmed: 22154968
Vet Rec. 1993 Apr 10;132(15):387-8
pubmed: 8080466
Parasitol Res. 2009 Sep;105(3):825-34
pubmed: 19452165
Vet Parasitol. 2012 Sep 30;189(1):85-8
pubmed: 22503039
IMA J Math Appl Med Biol. 1987;4(4):279-93
pubmed: 3503094
Vet Parasitol. 2014 Jun 16;203(1-2):114-9
pubmed: 24661808
Parasitol Res. 2010 May;106(6):1475-9
pubmed: 20155368
Int J Parasitol. 1996 Aug-Sep;26(8-9):993-1000
pubmed: 8923146
Vet Parasitol. 2013 Nov 15;198(1-2):154-8
pubmed: 23993637
Vet Res. 2002 Sep-Oct;33(5):531-45
pubmed: 12387488
Vet Parasitol. 2004 Feb 6;119(4):277-306
pubmed: 15154594
Vet Rec. 2015 May 23;176(21):546
pubmed: 25762583
Vet Parasitol. 2001 Jun 28;97(4):253-9
pubmed: 11390078
Parasitol Int. 2020 Jun;76:102063
pubmed: 31978599
Parasite. 2014;21:37
pubmed: 25076056
Vet Parasitol. 2012 May 4;186(1-2):10-7
pubmed: 22188982
Vet Clin North Am Food Anim Pract. 2020 Mar;36(1):31-43
pubmed: 32029187
Vet Parasitol. 2009 Sep 16;164(1):53-8
pubmed: 19409707
Onderstepoort J Vet Res. 1989 Mar;56(1):41-9
pubmed: 2726192
Vet Parasitol. 2009 Sep 16;164(1):3-11
pubmed: 19450930
Trends Parasitol. 2001 Sep;17(9):445-53
pubmed: 11530357
Vet Parasitol. 2011 Aug 4;180(1-2):144-54
pubmed: 21705144
Vet Rec. 1989 Aug 12;125(7):153-4
pubmed: 2800272
Trends Parasitol. 2006 Jun;22(6):253-61
pubmed: 16632404
BMC Vet Res. 2020 Aug 3;16(1):270
pubmed: 32746828
Vet Clin North Am Food Anim Pract. 2011 Mar;27(1):163-173
pubmed: 21215900