Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort.
Autoimmune pancreatitis
Cholangiocarcinoma
IgG4-related disease
IgG4-related sclerosing cholangitis
Isolated IgG4-related sclerosing cholangitis
Primary sclerosing cholangitis
Journal
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
ISSN: 1878-3562
Titre abrégé: Dig Liver Dis
Pays: Netherlands
ID NLM: 100958385
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
05
01
2021
revised:
05
02
2021
accepted:
07
02
2021
pubmed:
6
3
2021
medline:
5
2
2022
entrez:
5
3
2021
Statut:
ppublish
Résumé
The clinical characteristics of IgG4-related sclerosing cholangitis (IgG4-SC) especially without autoimmune pancreatitis (AIP) have not been investigated in a large cohort. To clarify the clinical characteristics of IgG4-SC and IgG4-SC without AIP. We retrospectively reviewed imaging, serology, other organ involvement (OOI) and histology of 872 patients with IgG4-SC who participated in a Japanese nationwide survey in 2019, and compared these items between IgG4-SC with and without AIP. AIP was present in 83.7% (730/872) of IgG4-SC. In IgG4-SC, bile duct wall thickening was observed on ultrasound (528/650; 81.2%), computed tomography (375/525; 71.4%) and magnetic resonance imaging or cholangiopancreatography (290/440; 65.9%). An elevated serum IgG4 level (≥ 135 mg/dL) was found in 88.0% (322/366). IgG4-related OOI other than AIP was observed in 25.2% (211/836). The proportion of females was significantly higher in IgG4-SC without AIP (28.9% vs. 20.1%; p = 0.025). Hilar stricture was the most common cholangiographic type in IgG4-SC without AIP (39/107; 36.4%).There were no significant differences between IgG4-SC with and without AIP in the rates of bile duct wall thickening, elevated serum IgG4 level, or IgG4-related OOI. The clinical characteristics of IgG4-SC was similar between IgG4-SC with and without AIP in a large cohort.
Sections du résumé
BACKGROUND
BACKGROUND
The clinical characteristics of IgG4-related sclerosing cholangitis (IgG4-SC) especially without autoimmune pancreatitis (AIP) have not been investigated in a large cohort.
AIMS
OBJECTIVE
To clarify the clinical characteristics of IgG4-SC and IgG4-SC without AIP.
METHODS
METHODS
We retrospectively reviewed imaging, serology, other organ involvement (OOI) and histology of 872 patients with IgG4-SC who participated in a Japanese nationwide survey in 2019, and compared these items between IgG4-SC with and without AIP.
RESULTS
RESULTS
AIP was present in 83.7% (730/872) of IgG4-SC. In IgG4-SC, bile duct wall thickening was observed on ultrasound (528/650; 81.2%), computed tomography (375/525; 71.4%) and magnetic resonance imaging or cholangiopancreatography (290/440; 65.9%). An elevated serum IgG4 level (≥ 135 mg/dL) was found in 88.0% (322/366). IgG4-related OOI other than AIP was observed in 25.2% (211/836). The proportion of females was significantly higher in IgG4-SC without AIP (28.9% vs. 20.1%; p = 0.025). Hilar stricture was the most common cholangiographic type in IgG4-SC without AIP (39/107; 36.4%).There were no significant differences between IgG4-SC with and without AIP in the rates of bile duct wall thickening, elevated serum IgG4 level, or IgG4-related OOI.
CONCLUSIONS
CONCLUSIONS
The clinical characteristics of IgG4-SC was similar between IgG4-SC with and without AIP in a large cohort.
Identifiants
pubmed: 33664004
pii: S1590-8658(21)00061-X
doi: 10.1016/j.dld.2021.02.009
pii:
doi:
Substances chimiques
Immunoglobulin G
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1308-1314Investigateurs
Keisuke Furumatsu
(K)
Shigeaki Sawai
(S)
Takuma Goto
(T)
Toshikatsu Okumura
(T)
Daisuke Suzuki
(D)
Masayuki Otsuka
(M)
Ikuhiro Kobori
(I)
Masaya Tamano
(M)
Mitsuhito Koizumi
(M)
Yoichi Hiasa
(Y)
Naoto Kawabe
(N)
Yoshiki Hirooka
(Y)
Satoshi Yamamoto
(S)
Yukio Asano
(Y)
Kazuo Inui
(K)
Akihiko Horiguchi
(A)
Hiroyuki Watanabe
(H)
Daishu Toya
(D)
Katsuko Hatayama
(K)
Toshiharu Ueki
(T)
Norikatsu Kinoshita
(N)
Mitsuru Sugimoto
(M)
Hiromasa Ohira
(H)
Tsuyoshi Mukai
(T)
Eiichi Tomita
(E)
Keisuke Iwata
(K)
Shogo Shimizu
(S)
Jun Suetsugu
(J)
Masahito Shimizu
(M)
Keiji Tsuji
(K)
Ryoko Ishida
(R)
Masanori Ito
(M)
Ryutaro Furukawa
(R)
Naoya Sakamoto
(N)
Masahiro Araki
(M)
Satoshi Tanno
(S)
Yasunari Sakamoto
(Y)
Tetsuhide Ito
(T)
Satoshi Takai
(S)
Shinichi Ikeya
(S)
Takanori Yamada
(T)
Norihiko Kudara
(N)
Akinori Shimizu
(A)
Keiji Hanada
(K)
Yasunori Ichiki
(Y)
Hideki Kitada
(H)
Michio Hifumi
(M)
Hiroyuki Kimura
(H)
Masayuki Kurosaki
(M)
Namiki Izumi
(N)
Hajime Sumi
(H)
Jun-Ichi Haruta
(JI)
Katsumi Hayashi
(K)
Ryo Harada
(R)
Masafumi Inoue
(M)
Shinichiro Nakamura
(S)
Tetsuya Ito
(T)
Ko Tomishima
(K)
Hiroyuki Isayama
(H)
Kyoko Oura
(K)
Tsutomu Masaki
(T)
Naoto Shimokawahara
(N)
Shirou Tanoue
(S)
Kousei Maemura
(K)
Akio Ido
(A)
Ichiro Mizushima
(I)
Mitsuhiro Kawano
(M)
Katsunori Yoshida
(K)
Makoto Naganuma
(M)
Miki Murata
(M)
Akiyoshi Nishio
(A)
Yuji Fujita
(Y)
Takuma Teratani
(T)
Shohei Matsubara
(S)
Hironao Tamai
(H)
Yuu Yoshida
(Y)
Ryousaku Azemoto
(R)
Ken Kamata
(K)
Tomohiro Watanabe
(T)
Takahiro Kurosu
(T)
Wasaburou Koizumi
(W)
Jun Fujita
(J)
Hideyuki Seki
(H)
Yasuhiro Ueda
(Y)
Takumi Fukumoto
(T)
Takuhiro Kousaki
(T)
Kazushige Uchida
(K)
Toshimasa Ochiai
(T)
Takeshi Kawasaki
(T)
Motohiko Tanaka
(M)
Etsuji Ishida
(E)
Kenji Notohara
(K)
Hideaki Mori
(H)
Toshiyuki Mori
(T)
Hideaki Kawabata
(H)
Masatoshi Miyata
(M)
Junichi Sakagami
(J)
Yoshito Itoh
(Y)
Masahiro Shiokawa
(M)
Hiroshi Seno
(H)
Noriko Watanabe
(N)
Itaru Naitoh
(I)
Hiromi Kataoka
(H)
Toshinori Aoki
(T)
Mitsuhiro Fujishiro
(M)
Toru Niihara
(T)
Hiroto Nishimata
(H)
Akira Mitoro
(A)
Hitoshi Yoshiji
(H)
Motoyuki Yoshida
(M)
Masafumi Ikeda
(M)
Kengo Tomita
(K)
Ryota Hokari
(R)
Kenji Hayasaka
(K)
Yuji Amano
(Y)
Kazuhiko Shioji
(K)
Kazunao Hayashi
(K)
Shuji Terai
(S)
Michiko Nakajima
(M)
Junya Yamahana
(J)
Ryusuke Matsumoto
(R)
Hideaki Kikuchi
(H)
Akira Kanamori
(A)
Seiki Kiriyama
(S)
Shinichi Iwatsu
(S)
Yuji Kato
(Y)
Shigeru Horiguchi
(S)
Takahito Yagi
(T)
Hiroyuki Okada
(H)
Kazuyoshi Ohkawa
(K)
Motohiro Hirao
(M)
Naoki Hiramatsu
(N)
Noriko Oza
(N)
Haruo Imamura
(H)
Takeshi Baba
(T)
Shigeru Nakano
(S)
Tetsuya Shinobi
(T)
Shomei Ryozawa
(S)
Masayo Motoya
(M)
Hiroshi Nakase
(H)
Noboru Kinoshita
(N)
Kei Ito
(K)
Tatsuya Miyake
(T)
Naruaki Kohge
(N)
Hiroshi Tobita
(H)
Satoru Joshita
(S)
Takeji Umemura
(T)
Shinya Kawaguchi
(S)
Kazuya Ohno
(K)
Koichi Sonobe
(K)
Akihiko Satoh
(A)
Tooru Shimosegawa
(T)
Fumihiko Miura
(F)
Minami Yagi
(M)
Keiji Sano
(K)
Atsushi Tanaka
(A)
Toshifumi Kin
(T)
Akio Katanuma
(A)
Kazuhiko Koike
(K)
Shin Miura
(S)
Atsushi Masamune
(A)
Youhei Kawashima
(Y)
Tatehiro Kagawa
(T)
Seishin Azuma
(S)
Mamoru Watanabe
(M)
Mitsuyoshi Honjyo
(M)
Takao Itoi
(T)
Akira Honda
(A)
Katsumasa Kobayashi
(K)
Toru Asano
(T)
Terumi Kamisawa
(T)
Suguru Mizuno
(S)
Kazuhiko Koike
(K)
Takayoshi Nishino
(T)
Hideaki Taniguchi
(H)
Kazuto Tajiri
(K)
Ichiro Yasuda
(I)
Yoshiya Tanaka
(Y)
Shinji Oe
(S)
Masaru Harada
(M)
Masanao Kurata
(M)
Mituharu Fukasawa
(M)
Nobuyuki Enomoto
(N)
Yuki Kawaji
(Y)
Masayuki Kitano
(M)
Yuko Nishise
(Y)
Hidetoshi Hirakawa
(H)
Tetsuya Ishizawa
(T)
Yoshiyuki Ueno
(Y)
Miyuki Kaino
(M)
Yuko Fujimoto
(Y)
Isao Sakaida
(I)
Kensuke Kubota
(K)
Informations de copyright
Copyright © 2021 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Authors declare no conflict of interests for this article.