Multinuclear MRI to disentangle intracellular sodium concentration and extracellular volume fraction in breast cancer.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 03 2021
04 03 2021
Historique:
received:
24
09
2020
accepted:
16
02
2021
entrez:
5
3
2021
pubmed:
6
3
2021
medline:
15
12
2021
Statut:
epublish
Résumé
The purpose of this work was to develop a novel method to disentangle the intra- and extracellular components of the total sodium concentration (TSC) in breast cancer from a combination of proton ([Formula: see text]H) and sodium ([Formula: see text]) magnetic resonance imaging (MRI) measurements. To do so, TSC is expressed as function of the intracellular sodium concentration ([Formula: see text]), extracellular volume fraction (ECV) and the water fraction (WF) based on a three-compartment model of the tissue. TSC is measured from [Formula: see text] MRI, ECV is calculated from baseline and post-contrast [Formula: see text]H [Formula: see text] maps, while WF is measured with a [Formula: see text]H chemical shift technique. [Formula: see text] is then extrapolated from the model. Proof-of-concept was demonstrated in three healthy subjects and two patients with triple negative breast cancer. In both patients, TSC was two to threefold higher in the tumor than in normal tissue. This alteration mainly resulted from increased [Formula: see text] ([Formula: see text] 30 mM), which was [Formula: see text] 130% greater than in healthy conditions (10-15 mM) while the ECV was within the expected range of physiological values (0.2-0.25). Multinuclear MRI shows promise for disentangling [Formula: see text] and ECV by taking advantage of complementary [Formula: see text]H and [Formula: see text] measurements.
Identifiants
pubmed: 33664340
doi: 10.1038/s41598-021-84616-9
pii: 10.1038/s41598-021-84616-9
pmc: PMC7933187
doi:
Substances chimiques
Protons
0
Sodium
9NEZ333N27
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5156Subventions
Organisme : NCI NIH HHS
ID : R21 CA213169
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066512
Pays : United States
Organisme : NIBIB NIH HHS
ID : R21 EB027263
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK106292
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK114428
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG061579
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB026456
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS097494
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB017183
Pays : United States
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