Taxifolin, Extracted from Waste
Animals
Anti-Inflammatory Agents, Non-Steroidal
/ chemistry
Apoptosis
/ drug effects
Carbon Tetrachloride
/ antagonists & inhibitors
Dose-Response Relationship, Drug
Hepatocytes
/ drug effects
Inflammation
/ drug therapy
Larix
/ chemistry
Liver Cirrhosis
/ chemically induced
Male
Mice
Mice, Inbred ICR
Molecular Conformation
Oxidative Stress
/ drug effects
Phosphatidylinositol 3-Kinases
/ metabolism
Plant Roots
/ chemistry
Proto-Oncogene Proteins c-akt
/ antagonists & inhibitors
Quercetin
/ analogs & derivatives
Signal Transduction
/ drug effects
Smad Proteins
/ antagonists & inhibitors
Structure-Activity Relationship
TOR Serine-Threonine Kinases
/ antagonists & inhibitors
Transforming Growth Factor beta1
/ antagonists & inhibitors
PI3K/AKT/mTOR pathway
TGF-β1/Smads
apoptosis
inflammation
liver fibrosis
taxifolin
Journal
Drug design, development and therapy
ISSN: 1177-8881
Titre abrégé: Drug Des Devel Ther
Pays: New Zealand
ID NLM: 101475745
Informations de publication
Date de publication:
2021
2021
Historique:
received:
11
09
2020
accepted:
21
12
2020
entrez:
5
3
2021
pubmed:
6
3
2021
medline:
8
10
2021
Statut:
epublish
Résumé
Taxifolin is a kind of dihydroflavone and is usually used as a food additive and health food for its antioxidant, anti-inflammatory, and anti-tumor activities. The purpose of this research is to probe into the hepatoprotective activity and the molecular mechanism of taxifolin. The liver fibrosis model was established by intraperitoneal injection of 5 mL/kg body weight of CCl The results indicated that CCl Taxifolin inhibited inflammation, and attenuated CCl
Identifiants
pubmed: 33664566
doi: 10.2147/DDDT.S281369
pii: 281369
pmc: PMC7924258
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Smad Proteins
0
TGFB1 protein, human
0
Transforming Growth Factor beta1
0
Quercetin
9IKM0I5T1E
taxifolin
9SOB9E3987
Carbon Tetrachloride
CL2T97X0V0
MTOR protein, human
EC 2.7.1.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
871-887Informations de copyright
© 2021 Liu et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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