Landscape of Monoclonal Antibodies Targeting Zika and Dengue: Therapeutic Solutions and Critical Insights for Vaccine Development.
Amino Acid Sequence
Antibodies, Monoclonal
/ genetics
Antibodies, Neutralizing
/ genetics
Antibodies, Viral
/ genetics
Antigens, Viral
/ chemistry
Cross Reactions
Dengue
/ prevention & control
Dengue Vaccines
/ immunology
Dimerization
Drug Design
Epitopes
/ chemistry
Humans
Models, Molecular
Protein Conformation
Protein Domains
Species Specificity
Structure-Activity Relationship
Viral Envelope Proteins
/ chemistry
Viral Vaccines
/ immunology
Virion
/ immunology
Zika Virus Infection
/ prevention & control
Dengue virus
Zika virus
monoclonal antibody
neutralizing antibody
therapeutics
vaccine
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
10
2020
accepted:
14
12
2020
entrez:
5
3
2021
pubmed:
6
3
2021
medline:
8
7
2021
Statut:
epublish
Résumé
The unprecedented 2015-2016 Zika outbreak in the Americas sparked global concern and drove the rapid deployment of vaccine and therapeutic countermeasures against this re-emerging pathogen. Alongside vaccine development, a number of potent neutralizing antibodies against Zika and related flaviviruses have been identified in recent years. High-throughput antibody isolation approaches have contributed to a better understanding of the B cell responses elicited following infection and/or vaccination. Structure-based approaches have illuminated species-specific and cross-protective epitopes of therapeutic value. This review will highlight previously described monoclonal antibodies with the best therapeutic potential against ZIKV and related flaviviruses, and discuss their implications for the rational design of better vaccine strategies.
Identifiants
pubmed: 33664734
doi: 10.3389/fimmu.2020.621043
pmc: PMC7921836
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Neutralizing
0
Antibodies, Viral
0
Antigens, Viral
0
Dengue Vaccines
0
Epitopes
0
Viral Envelope Proteins
0
Viral Vaccines
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
621043Informations de copyright
Copyright © 2021 Dussupt, Modjarrad and Krebs.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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