Dietary Taxifolin Protects Against Dextran Sulfate Sodium-Induced Colitis
NF-κB
colitis
gut microbiota
inflammatory bowel disease
intestinal barrier
taxifolin
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
11
2020
accepted:
29
12
2020
entrez:
5
3
2021
pubmed:
6
3
2021
medline:
24
6
2021
Statut:
epublish
Résumé
Taxifolin is a natural antioxidant polyphenol with various bioactivities and has many beneficial effects on human gut health. However, little is known of its function on colitis. In this study, the protective effects of taxifolin on colitis symptoms, inflammation, signaling pathways, and colon microbiota were investigated using dextran sulfate sodium (DSS)-induced colitis mice. Intriguingly, pre-administration of taxifolin alleviated the colitis symptoms and histological changes of the DSS-challenged mice. Supplementation of taxifolin significantly inhibited the secretions of tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 and significantly increased the secretions of IL-10, secretory immunoglobulin A, superoxide dismutase, and immunoglobulins (IgA, IgG, and IgM) in DSS-induced colitis mice. In addition, the activation of nuclear factor kappa B (NF-
Identifiants
pubmed: 33664740
doi: 10.3389/fimmu.2020.631809
pmc: PMC7921741
doi:
Substances chimiques
NF-kappa B
0
Dextran Sulfate
9042-14-2
Quercetin
9IKM0I5T1E
taxifolin
9SOB9E3987
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
631809Informations de copyright
Copyright © 2021 Hou, Hu, Zhang, Gao, Ma and Xu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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