Upregulation of microRNA-181a-5p increases the sensitivity of HS578T breast cancer cells to cisplatin by inducing vitamin D receptor-mediated cell autophagy.
autophagy
breast cancer
cisplatin
microRNA-181a-5p
Journal
Oncology letters
ISSN: 1792-1074
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
22
06
2020
accepted:
30
11
2020
entrez:
5
3
2021
pubmed:
6
3
2021
medline:
6
3
2021
Statut:
ppublish
Résumé
Breast cancer (BC) is the leading cause of death in females worldwide. Although cisplatin is a strong-effect and broad-spectrum chemotherapy drug, resistance to cisplatin remains a significant factor effecting clinical efficacy. The underlying mechanism of cancer cell resistance to cisplatin is not fully understood. MicroRNAs (miRs/miRNAs), as a regulator, are involved in regulating chemosensitivity to numerous chemotherapeutic drugs. The present study aimed to investigate the function of miR-181a-5p as a potential tumor suppressor in improving the efficiency of cisplatin in BC. The IC
Identifiants
pubmed: 33664811
doi: 10.3892/ol.2021.12508
pii: OL-0-0-12508
pmc: PMC7882884
doi:
Types de publication
Journal Article
Langues
eng
Pagination
247Informations de copyright
Copyright: © Lin et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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