Post-mortem biopsy of a patient with late exacerbation of COVID-19 pneumonia.
COVID‐19
PCR
late exacerbation
post‐mortem biopsy
Journal
Respirology case reports
ISSN: 2051-3380
Titre abrégé: Respirol Case Rep
Pays: United States
ID NLM: 101631052
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
23
12
2020
revised:
17
01
2021
accepted:
29
01
2021
entrez:
5
3
2021
pubmed:
6
3
2021
medline:
6
3
2021
Statut:
epublish
Résumé
Pathological findings of coronavirus disease (COVID-19) have rarely been reported owing to its contagious nature. Here, we treated an 82-year-old man whose condition was diagnosed as COVID-19 pneumonia, which exacerbated approximately 25 days after the initial onset. The patient died despite receiving intensive care. Post-mortem percutaneous needle biopsy of the lungs and liver tissue was performed, including genomic analysis, immunochemical tests, and pathological studies. Histopathology of the lungs showed both exudative and organizing diffuse alveolar damage. Supposedly, the organizing phase of acute respiratory distress syndrome (ARDS) induced COVID-19. Polymerase chain reaction (PCR) test and immunostaining of biopsy specimens showed negative results for COVID-19. Post-mortem percutaneous needle biopsy was more effective in reducing the risk of contagiousness than autopsy.
Identifiants
pubmed: 33664958
doi: 10.1002/rcr2.724
pii: RCR2724
pmc: PMC7900585
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e00724Informations de copyright
© 2021 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.
Références
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Clin Chim Acta. 2020 Oct;509:280-287
pubmed: 32531256
Emerg Infect Dis. 2020 Sep;26(9):
pubmed: 32412897
J Clin Pathol. 2020 May;73(5):239-242
pubmed: 32198191
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264