Where are the children in national hepatitis C policies? A global review of national strategic plans and guidelines.

BACKGROUND & AIMS

It is estimated that 3.26 million children and adolescents worldwide have chronic HCV infection. To date, the global response has focused on the adult population, but direct-acting antiviral (DAA) regimens are now approved for children aged ≥3 years. This global review describes the current status of policies on HCV testing and treatment in children, adolescents, and pregnant women in WHO Member States.

METHODS

We identified national strategic plans and/or clinical practice guidelines (CPGs) for HCV infection from a World Health Organization (WHO) database of national policies from Member States as of August 2019. A standardised

RESULTS

National HCV policies were available for 122 of the 194 WHO Member States. Of these, the majority (n = 71/122, 58%) contained no policy recommendations for either testing or treatment in children or adolescents. Of the 51 countries with policies, 24 had specific policies for both testing and treatment, and were mainly from the European region; 18 countries for HCV testing only (12 from high- or upper-middle income); and 9 countries for treatment only (7 high- or upper-middle income). Twenty-one countries provided specific treatment recommendations: 13 recommended DAA-based regimens for adolescents ≥12 years and 6 still recommended interferon/ribavirin-based regimens.

CONCLUSIONS

There are significant gaps in policies for HCV-infected children and adolescents. Updated guidance on testing and treatment with newly approved DAA regimens for younger age groups is needed, especially in most affected countries.

LAY SUMMARY

To date, the predominant focus of the global response towards elimination of hepatitis C has been on the testing and treatment of adults. Much less attention has been paid to testing and treatment among children and adolescents, although in 2018 an estimated 3.26 million were infected with HCV. Our review shows that many countries have no national guidance on HCV testing and treatment in children and adolescents. It highlights the urgent need for advocacy and updated policies and guidelines specific for children and adolescents.

Informations de copyright

© 2021 The Author(s).

Déclaration de conflit d'intérêts

FM, AM, PC, HB, and PE declare no competing interests. CT has previously received grant funding from 10.13039/100010877ViiV Healthcare and BMS (through Penta Foundation). IJC reports grants from 10.13039/100006483Abbvie, 10.13039/100008021Bristol Myers Squibb, 10.13039/100016016Gilead, 10.13039/100008897Janssen Pharmaceuticals, and 10.13039/100010877ViiV Healthcare (through the PENTA Foundation). Please refer to the accompanying ICMJE disclosure forms for further details.