Apolipoprotein E genotype-dependent nutrigenetic effects to prebiotic inulin for modulating systemic metabolism and neuroprotection in mice via gut-brain axis.
APOE
MRI
Nutrigenetics
Prebiotics
Short chain fatty acids
blood–brain barrier
gut microbiome
inulin
metabolomics
Journal
Nutritional neuroscience
ISSN: 1476-8305
Titre abrégé: Nutr Neurosci
Pays: England
ID NLM: 100892202
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
pubmed:
6
3
2021
medline:
2
8
2022
entrez:
5
3
2021
Statut:
ppublish
Résumé
The goal of the study was to identify the potential nutrigenetic effects to inulin, a prebiotic fiber, in mice with different human apolipoprotein E (APOE) genetic variants. Specifically, we compared responses to inulin for the potential modulation of the systemic metabolism and neuroprotection via gut-brain axis in mice with human We performed experiments with young mice expressing the human In both We found that inulin had many similar beneficial effects in the gut and brain for both
Identifiants
pubmed: 33666538
doi: 10.1080/1028415X.2021.1889452
pmc: PMC8799401
mid: NIHMS1675571
doi:
Substances chimiques
Apolipoprotein E4
0
Apolipoproteins E
0
Prebiotics
0
Inulin
9005-80-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1669-1679Subventions
Organisme : NIA NIH HHS
ID : R01 AG075583
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007778
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054459
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA177558
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG039621
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG062480
Pays : United States
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